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合成代谢雄激素类固醇滥用所致心肌病

Cardiomyopathy induced by anabolic-androgenic steroid abuse.

作者信息

Garner Orlando, Iardino Alfredo, Ramirez Ana, Yakoby Maty

机构信息

Internal Medicine, Texas Tech University Health Science Center at the Permian Basin, Odessa, Texas, USA.

出版信息

BMJ Case Rep. 2018 Jul 23;2018:bcr-2017-223891. doi: 10.1136/bcr-2017-223891.

Abstract

Bodybuilders use anabolic-androgenic steroids to increase muscle mass, but abuse of these hormones has been related to cardiomyopathy in the past. A 60-year-old Caucasian male bodybuilder with medical history of male hypogonadism and on testosterone replacement therapy, allegedly preparing for a weightlifting competition and receiving stem cell infusions from his trainer, is transferred to the intensive care unit for worsening shortness of breath after failing treatment for community-acquired pneumonia. Chest X-ray on transfer was suggestive of pulmonary oedema, and transthoracic echocardiography showed an ejection fraction of 25%-30%. The patient was taken for cardiac catheterisation, which yielded non-ischaemic cardiomyopathy. His testosterone levels were supratherapeutic. Anabolic-androgenic steroid abuse can be a cause of cardiomyopathy in patients who have no other risk factor for such disease.

摘要

健美运动员使用合成代谢雄激素类固醇来增加肌肉量,但过去滥用这些激素与心肌病有关。一名60岁的白人男性健美运动员,有男性性腺功能减退病史且正在接受睾酮替代治疗,据称他正在为一场举重比赛做准备,并从他的教练那里接受干细胞输注,在社区获得性肺炎治疗失败后,因呼吸急促加重被转入重症监护病房。转院时的胸部X光片提示肺水肿,经胸超声心动图显示射血分数为25%-30%。患者接受了心导管检查,结果显示为非缺血性心肌病。他的睾酮水平高于治疗剂量。在没有其他此类疾病风险因素的患者中,滥用合成代谢雄激素类固醇可能是心肌病的一个病因。

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