Parfenov V A, Zhivolupov S A, Nikulina K V, Poverennova I E, Lapatuhin V G, Zhestikova M G, Zhukova N G, Glazunov A B
Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
St Petersburg Medical Academy, St Petersburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6):15-23. doi: 10.17116/jnevro20181186115.
To investigate the efficacy of divaza in outpatients with cognitive disorders and chronic brain ischemia (CBI).
The non-interventional observational program included the data of 2583 outpatients with CBI from 30 cities (8 federal okrugs of the Russian Federation) who were on outpatient neurological treatment and received divaza in a dose of 2 tablets three times a day from Oct 2016 to Jan 2017. Cognitive functions were evaluated using the MoCA scale before and after 3 months of treatment.
Cognitive disorders were identified in 90.7% of patients (<26 MoCA scores). After treatment, the mean MoCA score increased from 19.58±5.13 to 23.99±4.21 (p<0.0001), the number of patients with normal cognitive functions rate (≥26 scores) increased from 9.3 to 41.3%, the number of patients with marked cognitive impairment decreased. The drug was well-tolerated by old and very old patients, adverse events were observed rarely (0.6% of cases). The majority of doctors (88.4%) noticed the effect of divaza as significant improvement or improvement, and 89.6% of patients valued the effect to be excellent or good. The use of divaza, the drug with endothelioprotective and nootropic effects, is pathogenetically justified and promising in patients with cognitive disorders of vascular etiology.
研究地伐西匹对认知障碍和慢性脑缺血（CBI）门诊患者的疗效。
非干预性观察项目纳入了来自30个城市（俄罗斯联邦8个联邦区）的2583例接受门诊神经治疗的CBI门诊患者的数据，这些患者在2016年10月至2017年1月期间每天服用3次、每次2片地伐西匹。在治疗3个月前后使用蒙特利尔认知评估量表（MoCA）评估认知功能。
90.7%的患者存在认知障碍（MoCA评分<26分）。治疗后，MoCA平均评分从19.58±5.13提高到23.99±4.21（p<0.0001），认知功能正常（≥26分）的患者比例从9.3%增加到41.3%，明显认知障碍的患者数量减少。老年和高龄患者对该药物耐受性良好，不良事件发生率很低（0.6%）。大多数医生（88.4%）注意到地伐西匹的效果显著改善或有所改善，89.6%的患者认为效果极佳或良好。对于血管病因导致认知障碍的患者，使用具有内皮保护和促智作用的地伐西匹在发病机制上是合理的，且前景广阔。
