Shavlovskaya O A
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):111-115. doi: 10.17116/jnevro2017117121111-115.
Disturbances of hemorheology, hemostasis and fibrinolysis play an important role in the pathogenesis and pathophysiology of chronic cerebral ischemia. Physiological functioning of the endothelium is disturbed under the action of damaging factors. Divaza is created on the basis of release-active antibodies to S100b protein and antibodies to endothelial NO-synthase. The efficacy of divaza in the treatment of chronic cerebral ischemia and related diseases (cognitive impairment, anxiety) was demonstrated. A normalizing effect of divaza in the dose of 2 tablets 3 times daily between meals during 12 weeks on endothelial function is shown.
血液流变学、止血和纤维蛋白溶解的紊乱在慢性脑缺血的发病机制和病理生理学中起重要作用。在损伤因素的作用下，内皮细胞的生理功能受到干扰。Divaza是基于针对S100b蛋白的释放活性抗体和针对内皮型一氧化氮合酶的抗体而制成的。Divaza在治疗慢性脑缺血及相关疾病（认知障碍、焦虑）方面的疗效得到了证实。结果显示，Divaza在12周内每日3次、每次2片、餐间服用的剂量下，对内皮功能具有正常化作用。
