Nyckowski Tim, McGregor Sean, Huang William W
1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, USA.
2 Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, USA.
J Oncol Pharm Pract. 2019 Jul;25(5):1271-1274. doi: 10.1177/1078155218788709. Epub 2018 Jul 24.
Gemcitabine is a chemotherapeutic agent used to treat several solid organ malignancies. The most common cutaneous toxicities are a mild erythematous rash and pruritus, which are often attributed to infectious etiologies. However, certain clinical characteristics may favor a drug-related reaction. Clinicians should recognize these phenomena to avoid potentially unnecessary antibiotic treatment or withdrawal of chemotherapeutic agents.
We aim to report a case of gemcitabine-related acute lipodermatosclerosis-like eruption, add to the evolving classification of this condition, and highlight developing literature on gemcitabine that may explain this toxicity.
Dermatology was consulted for presumed cellulitis in a 62-year-old female with pancreatic carcinoma. The patient presented to the emergency department five days after her first dose of gemcitabine with erythema in both lower extremities. A diagnosis of gemcitabine-related acute lipodermatosclerosis was made and the patient was started on topical triamcinolone.
It is important to recognize gemcitabine-related acute lipodermatosclerosis in order to avoid unnecessary antibiotic use and disruptions in chemotherapy.
吉西他滨是一种用于治疗多种实体器官恶性肿瘤的化疗药物。最常见的皮肤毒性是轻度红斑疹和瘙痒，这些通常归因于感染性病因。然而，某些临床特征可能提示药物相关反应。临床医生应认识到这些现象，以避免潜在的不必要的抗生素治疗或化疗药物的停用。
我们旨在报告一例吉西他滨相关的急性脂膜炎样皮疹病例，补充这种病症不断发展的分类，并强调有关吉西他滨的文献，这些文献可能解释这种毒性。
一名62岁患有胰腺癌的女性因疑似蜂窝织炎而咨询皮肤科。患者在首次使用吉西他滨五天后到急诊科就诊，双下肢出现红斑。诊断为吉西他滨相关的急性脂膜炎样皮疹，患者开始外用曲安奈德。
认识到吉西他滨相关的急性脂膜炎样皮疹很重要，以避免不必要的抗生素使用和化疗中断。
