Orthopedic Department, Affiliated Hong Qi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China.
Anesthesiology Department, Affiliated Hong Qi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China.
J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4):891-897.
The aim of this study was to explore the clinical efficacy of limb-salvage therapy for malignant bone tumors of the limbs using two surgical methods. This investigation presents a retrospective study of malignant bone tumors of the limbs in 42 patients. Participants were divided into two groups: group A of 25 patients who were treated with artificial prosthesis replacement, and group B of 17 patients treated with bone inactivation. By collection of clinical data, the survival rate, surgical complications, quality of life, pain relief and postoperative limb function following artificial prosthesis replacement and tumor inactivation were comprehensively evaluated in patients with malignant bone tumors of the limbs. Group A had significantly higher Karnofsky quality of life scores compared to group B after six months (P=0.027). The Enneking scores of limb functions in group A were significantly higher than those of group B (P=0.022). In group A the postoperative limb function score was good and excellent in 92% and in group B in 64.7%. There were significantly more postoperative complications in group B compared with group A (P=0.027), but no significant difference in the recurrence rate in the two group (P=0.976). The study results can provide reference for surgical treatment of the patients with malignant bone tumors.
本研究旨在探讨两种手术方法治疗肢体恶性骨肿瘤的临床疗效。该研究回顾性分析了 42 例肢体恶性骨肿瘤患者。将患者分为两组：A 组 25 例采用人工假体置换治疗，B 组 17 例采用灭活骨治疗。通过收集临床资料，综合评价人工假体置换和肿瘤灭活治疗肢体恶性骨肿瘤患者的生存率、手术并发症、生活质量、疼痛缓解及术后肢体功能。6 个月后，A 组的 Karnofsky 生活质量评分明显高于 B 组（P=0.027）。A 组的肢体功能 Enneking 评分明显高于 B 组（P=0.022）。A 组术后肢体功能评分优良率为 92%，B 组为 64.7%。B 组术后并发症明显多于 A 组（P=0.027），但两组复发率无明显差异（P=0.976）。研究结果可为恶性骨肿瘤患者的手术治疗提供参考。
