He Xiaojun, Gao Zhenzhen, Xu Hongwei, Zhang Zhongwei, Fu Peng
Department of Orthopedics, The Second Affiliated Hospital of Jiaxing College, 1518 Huancheng Rd, 314000, Jiaxing, China.
Department of Oncology, The Second Affiliated Hospital of Jiaxing College, Jiaxing, China.
J Orthop Surg Res. 2017 Jan 13;12(1):5. doi: 10.1186/s13018-016-0500-0.
Osteosarcoma is a high malignant neoplasm, and conflicting findings have been reported on the survival and function recovery of osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared limb salvage surgery (LSS) with amputation in clinical outcomes of osteosarcoma patients by a meta-analysis.
The survival rate of osteosarcoma patients was collected from research reports from CNKI, MEDLINE, EMBASE, the Cochrane Database, and Google Scholar till April 30, 2016. The quality of including articles was evaluated by two independent reviewers. Differences between patients undergoing limb salvage surgery and amputation were analyzed based on postoperative survival rates.
Ten articles were included according to selection criteria. There were 1343 patients in total from these studies. Our results showed that there was no significant difference between limb salvage surgery and amputation according to local recurrence; however, patients with limb salvage surgery had a higher 5-year overall survival.
LSS results in higher 5-year survival rates and better survival, while not increasing the risk of local recurrence. This study provided more evidences to support limb salvage surgery as a considerable treatment of osteosarcoma patients.
骨肉瘤是一种高度恶性肿瘤，关于接受保肢手术或截肢手术的骨肉瘤患者的生存率和功能恢复情况，已有相互矛盾的研究结果报道。在本研究中，我们通过荟萃分析比较了保肢手术（LSS）和截肢手术对骨肉瘤患者临床结局的影响。
从中国知网、MEDLINE、EMBASE、考克兰数据库和谷歌学术搜索中收集截至2016年4月30日的骨肉瘤患者生存率研究报告。由两名独立评审员评估纳入文章的质量。根据术后生存率分析接受保肢手术和截肢手术患者之间的差异。
根据选择标准纳入10篇文章。这些研究共纳入1343例患者。我们的结果显示，就局部复发而言，保肢手术和截肢手术之间无显著差异；然而，接受保肢手术的患者5年总生存率更高。
保肢手术可提高5年生存率并改善生存状况，同时不会增加局部复发风险。本研究提供了更多证据支持保肢手术作为骨肉瘤患者的一种可行治疗方法。
