克罗恩病患者的内脏脂肪增加：与健康对照的比较分析

VISCERAL FAT IS INCREASED IN INDIVIDUALS WITH CROHN'S DISEASE: A COMPARATIVE ANALYSIS WITH HEALTHY CONTROLS.

作者信息

Magro Daniéla Oliveira, Barreto Maria Rita Lazzarini, Cazzo Everton, Camargo Michel Gardere, Kotze Paulo Gustavo, Coy Claudio Saddy Rodrigues

机构信息

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Cirurgia, Campinas, SP, Brasil.

Pontifícia Universidade Católica do Paraná, Hospital Universitário Cajuru, Unidade de Cirurgia Colorretal, Curitiba, PR, Brasil.

出版信息

Arq Gastroenterol. 2018 Apr-Jun;55(2):142-147. doi: 10.1590/S0004-2803.201800000-25.

DOI:10.1590/S0004-2803.201800000-25

PMID:30043863

Abstract

BACKGROUND

It is known that obesity is associated with a chronic inflammatory state, but few studies have evaluated visceral fat (VF) content and its role in individuals with Crohn's disease (CD).

OBJETIVE

To compare the nutritional status, body composition and proportion of VF between CD individuals and healthy volunteers.

METHODS

Cross-sectional study that enrolled individuals with Crohn's disease and healthy controls. The stratification according to nutritional status was carried out by means of BMI. The percentage of body fat percentage (%BF) and VF were estimated by means of DEXA. VF proportion was evaluated by means of the VF/BMI and VF/%BF ratios.

RESULTS

A total of 78 individuals were included. The control group was comprised of 28 healthy subjects aged 35.39±10 years old (60.7% women); mean BMI=23.94±3.34 kg/m2; mean VF=511.82±448.68 g; mean CRP=0.81±1.78 ng/mL. The CD group was comprised of 50 patients; 11 (22%) were underweight (BMI=18.20±1.97 kg/ m2; %BF=24.46±10.01; VF=217.18±218.95 g; CRP=4.12±4.84 ng/mL); 18 (36%) presented normal weight (BMI=22.43±1.48 kg/m2; %BF=30.92±6.63; VF=542.00±425.47 g and CRP=4.40±1.78 ng/mL); 21 (42%) were overweight or obese (BMI=29.48±3.78 kg/m2; %BF=39.91±7.33; VF=1525.23±672.7 g and CRP=1.33±2.06 ng/mL). The VF/BMI ratio was higher in the CD group when compared to controls (32.41±24.63 vs 20.01±16.23 g per BMI point; P=0.02). Likewise, the VF/%BF was also higher in the CD group (35.21±23.33 vs 15.60±12.55 g per percentage point; P<0.001).

CONCLUSION

Among individuals with Crohn's disease, BMI presents a direct correlation with visceral fat content. These results indicate the presence of an adiposopathy in Crohn's disease subjects, which is evidenced by a higher visceral fat.

摘要

背景

已知肥胖与慢性炎症状态相关，但很少有研究评估克罗恩病（CD）患者的内脏脂肪（VF）含量及其作用。

目的

比较CD患者与健康志愿者的营养状况、身体成分和VF比例。

方法

一项横断面研究，纳入了克罗恩病患者和健康对照。根据BMI对营养状况进行分层。通过双能X线吸收法（DEXA）估算体脂百分比（%BF）和VF。通过VF/BMI和VF/%BF比值评估VF比例。

结果

共纳入78例个体。对照组由28名健康受试者组成，年龄为35.39±10岁（60.7%为女性）；平均BMI = 23.94±3.34 kg/m²；平均VF = 511.82±448.68 g；平均C反应蛋白（CRP）= 0.81±1.78 ng/mL。CD组由50例患者组成；11例（22%）体重过轻（BMI = 18.20±1.97 kg/m²；%BF = 24.46±10.01；VF = 217.18±218.95 g；CRP = 4.12±4.84 ng/mL）；18例（36%）体重正常（BMI = 22.43±1.48 kg/m²；%BF = 30.92±6.63；VF = 542.00±425.47 g且CRP = 4.40±1.78 ng/mL）；21例（42%）超重或肥胖（BMI = 29.48±3.78 kg/m²；%BF = 39.91±7.33；VF = 1525.23±672.7 g且CRP = 1.33±2.06 ng/mL）。与对照组相比，CD组的VF/BMI比值更高（每BMI单位为32.41±24.63 vs 20.01±16.23 g；P = 0.02）。同样，CD组的VF/%BF也更高（每百分点为35.21±23.33 vs 15.60±12.55 g；P < 0.001）。