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子宫腺肌病患者与月经相关的弥散性血管内凝血:病例报告及文献复习

Menstruation-related disseminated intravascular coagulation in an adenomyosis patient: case report and review of the literature.

作者信息

Cernogoraz Alice, Schiraldi Luigi, Bonazza Deborah, Ricci Giuseppe

机构信息

a Department of Medical Science , Università di Trieste , Trieste , Italy.

b Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" , Trieste , Italy.

出版信息

Gynecol Endocrinol. 2019 Jan;35(1):32-35. doi: 10.1080/09513590.2018.1488956. Epub 2018 Jul 25.

Abstract

Disseminated intravascular coagulation (DIC) is a high mortality coagulopathy that leads to simultaneous thrombotic and bleeding problems. It occurs as a complication in different disease as malignancies, obstetrical catastrophes, bacterial sepsis and traumas. We report on an extremely rare case of acute DIC in a patient with misdiagnosed adenomyosis and massive methrorragia which led to acute kidney failure. The patient was successfully treated with hysterectomy and blood product transfusions; however, a slight reduction of renal function persisted. We were able to confirm the cause-consequence link between adenomyosis and consumptive DIC since we saw the thrombi in the adenomyotic uterus from early hysterectomy specimen. Moreover, this is the first case, for the best of our knowledge, in which systemic consequences persist in an adenomyosis patient who developed a DIC. Early diagnose and treatment of acute DIC is essential for patient's survival and to prevent severe complications: adenomyosis should be kept in mind as a possible cause of DIC when a patient shows up with massive bleeding.

摘要

弥散性血管内凝血(DIC)是一种死亡率很高的凝血病,可导致同时出现血栓形成和出血问题。它作为一种并发症出现在不同疾病中,如恶性肿瘤、产科灾难、细菌性败血症和创伤。我们报告了一例极为罕见的急性DIC病例,该患者患有误诊的子宫腺肌病并出现大量子宫出血,进而导致急性肾衰竭。患者通过子宫切除术和输血治疗成功治愈;然而,肾功能仍有轻微下降。我们能够证实子宫腺肌病与消耗性DIC之间的因果关系,因为我们在早期子宫切除标本的子宫腺肌病组织中发现了血栓。此外,据我们所知,这是首例子宫腺肌病患者发生DIC后出现全身后果持续存在的病例。急性DIC的早期诊断和治疗对于患者的生存以及预防严重并发症至关重要:当患者出现大量出血时,应考虑子宫腺肌病可能是DIC的病因。

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