Pak Stella, Yatsynovich Yan, Valencia Damian, Chen Tian
From the Department of Medicine, Kettering Medical Center, Kettering, OH.
Department of Mathematics and Statistics, Toledo University, Toledo, OH.
Crit Pathw Cardiol. 2018 Sep;17(3):161-166. doi: 10.1097/HPC.0000000000000150.
Hyperuricemia has been recently speculated to be associated with the development of atrial fibrillation (AF). A meta-analysis of observational studies was conducted to explore the relationship between serum uric acid (SUA) and AF. We searched the MEDLINE, EMBASE, and CINAHL databases and performed extensive bibliography search to identify studies with mean SUA level for patients with and without AF. Key search terms were "atrial fibrillation" and "uric acid." Under the random-effects model, the pooled standardized difference in means between patients with and without AF was calculated. A total of 24 studies with 30,609 patients were included for quantitative analyzation of the difference in SUA levels between the patients with and without AF. The SUA level of patients with atrial AF was found to be significantly higher compared with those without AF (standardized difference in means = 0.66; 95% confidence interval, 0.43-0.88; P < 0.0001). The mean SUA level of patients with AF significantly is higher than those without AF.
近期有推测认为高尿酸血症与心房颤动（AF）的发生有关。我们进行了一项观察性研究的荟萃分析，以探讨血清尿酸（SUA）与AF之间的关系。我们检索了MEDLINE、EMBASE和CINAHL数据库，并进行了广泛的文献检索，以确定有和没有AF的患者的平均SUA水平的研究。关键检索词为“心房颤动”和“尿酸”。在随机效应模型下，计算有和没有AF的患者之间合并的标准化平均差异。共有24项研究、30609例患者纳入，用于定量分析有和没有AF的患者之间SUA水平的差异。发现心房颤动患者的SUA水平显著高于没有AF的患者（标准化平均差异=0.66；95%置信区间，0.43-0.88；P<0.0001）。AF患者的平均SUA水平显著高于没有AF的患者。
