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高尿酸血症和痛风与心房颤动风险相关：一项更新的荟萃分析。

Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis.

作者信息

Deng Yingjian, Li Qiang, Zhou Faguang, Cai Binni, Guo Jincun, Li Guiyang, Li Linlin, Su Xin, Liu Jianghai, Chang Dong

机构信息

Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, 361000 Xiamen, Fujian, China.

出版信息

Rev Cardiovasc Med. 2022 May 16;23(5):178. doi: 10.31083/j.rcm2305178. eCollection 2022 May.

DOI:10.31083/j.rcm2305178
PMID:39077615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273668/
Abstract

BACKGROUND

Although it has been suggested that hyperuricemia and gout are predictive of the future risk of atrial fibrillation, there is still a lack of epidemiological evidence.

OBJECTIVE

Through an updated systematic review and meta-analysis, we aimed to assess the association between hyperuricemia/gout and atrial fibrillation.

METHODS

We performed a systematic search of EMBASE, PubMed, and Web of Science from their establishment to September 2021 for all relevant studies of hyperuricemia or gout and atrial fibrillation. Meta-analysis was conducted using the random-effects method to calculate the overall relative risk (RR) and 95% confidence intervals (CI), and subgroup analyses were performed on data subsets by geographic location and study design.

RESULT

A total of 12 studies were included in this study. The results from 8 studies showed that hyperuricemia was associated with an increased incidence of atrial fibrillation (RR: 1.83, 95% CI: 1.35-2.47), but significant association was only observed in studies in China (RR: 1.88, 95% CI: 1.31-2.71) and cross-sectional studies (RR: 2.35, 95% CI: 1.97-2.81) rather than studies in Japan (RR: 1.74, 95% CI: 0.71-4.23) and cohort studies (RR: 1.20, 95% CI: 0.99-1.46). The results from 4 studies showed that gout was also associated with an increased risk of AF (RR: 1.33, 95% CI: 1.04-1.71).

CONCLUSIONS

Hyperuricemia and gout are associated with an increased incidence of atrial fibrillation.

摘要

背景

尽管有研究表明高尿酸血症和痛风可预测未来房颤风险，但仍缺乏流行病学证据。

目的

通过更新的系统评价和荟萃分析，评估高尿酸血症/痛风与房颤之间的关联。

方法

我们对EMBASE、PubMed和Web of Science从建库至2021年9月进行了系统检索，纳入所有关于高尿酸血症或痛风与房颤的相关研究。采用随机效应模型进行荟萃分析，计算总体相对风险（RR）和95%置信区间（CI），并按地理位置和研究设计对数据子集进行亚组分析。

结果

本研究共纳入12项研究。8项研究结果显示，高尿酸血症与房颤发病率增加相关（RR：1.83，95%CI：1.35-2.47），但仅在中国的研究（RR：1.88，95%CI：1.31-2.71）和横断面研究（RR：2.35，95%CI：1.97-2.81）中观察到显著关联，而在日本的研究（RR：1.74，95%CI：0.71-4.23）和队列研究（RR：1.20，95%CI：0.99-1.46）中未观察到。4项研究结果显示，痛风也与房颤风险增加相关（RR：1.33，95%CI：1.04-1.71）。

结论

高尿酸血症和痛风与房颤发病率增加相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/85aa6acbdb6d/2153-8174-23-5-178-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/d7196168e08c/2153-8174-23-5-178-g1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/85aa6acbdb6d/2153-8174-23-5-178-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/d7196168e08c/2153-8174-23-5-178-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/faad2372dda4/2153-8174-23-5-178-g2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/3c824e79325e/2153-8174-23-5-178-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/eedfd20415f1/2153-8174-23-5-178-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/7fb42f4b35b9/2153-8174-23-5-178-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eedb/11273668/85aa6acbdb6d/2153-8174-23-5-178-g7.jpg

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