[射频消融联合聚桂醇治疗婴幼儿腮腺血管瘤的临床研究]

[Clinical study of radiofrequency ablation combined with lauromacrogol for the treatment of parotid gland hemangioma in infants].

作者信息

Han Tao, Chen Haini, Zou Jijun, Ji Yi, Chen Jianbing, Shen Weimin, Cui Jie

出版信息

Zhonghua Zheng Xing Wai Ke Za Zhi. 2016 Jul;32(4):254-8.

Abstract

OBJECTIVE

To investigate the clinical effect of radiofrequency ablation (RFA) combined with lauromacrogol for the treatment of parotid gland hemangioma in infants.

METHODS

From Sep.2005 to Dec.2014,a total of 117 patients with parotid gland hemangioma were divided into observation group (n =32),control group 1 (n =30),control group 2 (n =28) and control group 3 (n =27).The observation group was treated by RFA combined with lauromacrogol, while the control group 1 was treated by RFA only, the control group 2 was treated by pingyangmycin only, and the control group 3 received additional pingyangmycin based on RFA. All the patients were followed up for 6 to 24 months, and the clinical effects were observed in four groups.

RESULTS

Control group 1:16 patients were cured (53.3％),and the number of patients with ≥2 treatments was 9.There was 1 case with skin ulceration,1 with abdominal discomfort,1 with liver function damage and 1 with high fever.Control group 2:17 patients were cured(60.7％),and number of patients with ≥2 treatments was 12.There were 3 cases with skin ulceration,9 with abdominal discomfort,6 with liver function damage and 5 with high fever.Control group 3:21 patients were cured(77.8％),and number of patients with ≥2 treatments was 2.There were 2 cases with skin ulceration,6 with abdominal discomfort,4 with liver function damage and 4 with high fever.However,in observation group,25 patients were cured(78.1％) and number of patients with ≥ 2 treatments was 4,which were significantly different from that in control group 1 or control group 2 (P ＜0.05).And the difference in postoperative adverse reactions between observation group and control group 2 or control group 3 was also of significance (2 with skin ulceration,1 with abdominal discomfort,1 with liver function damage and 6 with high fever,P ＜ 0.05).

CONCLUSIONS

Combined RFA and lauromacrogol has a good therapeutic effect on parotid gland hemangioma with relatively low adverse effect, so it deserves to be suggested and applied in clinical practice.

摘要

目的

探讨射频消融（RFA）联合聚桂醇治疗婴幼儿腮腺血管瘤的临床效果。

方法

2005年9月至2014年12月，将117例腮腺血管瘤患者分为观察组（n = 32）、对照组1（n = 30）、对照组2（n = 28）和对照组3（n = 27）。观察组采用RFA联合聚桂醇治疗，对照组1仅采用RFA治疗，对照组2仅采用平阳霉素治疗，对照组3在RFA基础上加用平阳霉素治疗。所有患者随访6至24个月，观察四组的临床效果。

结果

对照组1：16例治愈（53.3％），接受≥2次治疗的患者有9例。有1例皮肤溃疡、1例腹部不适、1例肝功能损害和1例高热。对照组2：17例治愈（60.7％），接受≥2次治疗的患者有12例。有3例皮肤溃疡、9例腹部不适、6例肝功能损害和5例高热。对照组3：21例治愈（77.8％），接受≥2次治疗的患者有2例。有2例皮肤溃疡、6例腹部不适、4例肝功能损害和4例高热。然而，观察组25例治愈（78.1％），接受≥2次治疗的患者有4例，与对照组1或对照组2相比差异有统计学意义（P ＜0.05）。观察组与对照组2或对照组3术后不良反应的差异也有统计学意义（2例皮肤溃疡、1例腹部不适、1例肝功能损害和6例高热，P ＜0.05）。