Department of Surgical Pathology, Uludag University, Faculty of Medicine, Bursa, Turkey.
Department of Urology, Uludag University, Faculty of Medicine, Bursa, Turkey.
Int Braz J Urol. 2019 Jan-Feb;45(1):68-73. doi: 10.1590/S1677-5538.IBJU.2018.0048.
In this study we aimed to review urological soft tissue sarcomas of genitourinary tract that were diagnosed in our institution and their prognostic factors for survival.
The clinical and pathological records of 31 patients who had diagnosis of soft tissue sarcomas primarily originating from the genitourinary tract between 2005-2011 were reviewed.
The most common site was kidney (17 cases, 54.8%), and most common diagnosis was leiomyosarcoma (11 cases, 35.4%). A total of 24 patients (77.4%) had surgical excision. The surgical margins were positive in 7 patients who presented with local recurrence after primary resection. Twelve patients developed metastatic disease. During follow-up (range 9-70 month), 26 of the 31 patients (88.9%) were alive. Significant survival differences were found according to histological type (p: 0.001), with lower survival rates for malignant fibrous histiocytoma. The tumor size, the presence of metastasis at the time of diagnosis and tumor localization were not statistically significant for overall survival.
In our series, prostate sarcomas, paratesticular rhabdomyosarcoma and malignant fibrous histiocytoma had poor prognosis, especially in patients presenting with metastatic disease.
本研究旨在回顾我们机构诊断的泌尿生殖系统软组织肉瘤及其生存的预后因素。
回顾了 2005 年至 2011 年间，31 名原发性起源于泌尿生殖系统的软组织肉瘤患者的临床和病理记录。
最常见的部位是肾脏（17 例，54.8%），最常见的诊断是平滑肌肉瘤（11 例，35.4%）。共有 24 名患者（77.4%）接受了手术切除。7 名患者在初次切除后出现局部复发，手术切缘阳性。12 名患者发生转移。在随访期间（9-70 个月），31 名患者中的 26 名（88.9%）存活。根据组织学类型，生存差异显著（p：0.001），恶性纤维组织细胞瘤的生存率较低。肿瘤大小、诊断时转移的存在和肿瘤定位与总生存率无统计学意义。
在我们的系列研究中，前列腺肉瘤、副睾横纹肌肉瘤和恶性纤维组织细胞瘤预后不良，尤其是伴有转移的患者。
