Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
J Leukoc Biol. 2018 Oct;104(4):701-715. doi: 10.1002/JLB.4RI0418-151R. Epub 2018 Jul 25.
The role of the microbiota in many diseases including cancer has gained increasing attention. Paired with this is our expanding appreciation for the heterogeneity of the neutrophil compartment regarding surface marker expression and functionality. In this review, we will discuss the influence of the microbiota on granulopoiesis and consequent activity of neutrophils in cancer. As evidence for this microbiota-neutrophil-cancer axis builds, it exposes new therapeutic targets to improve a cancer patient's outcome.
微生物群在许多疾病（包括癌症）中的作用引起了越来越多的关注。与此同时，我们也越来越认识到中性粒细胞区室在表面标志物表达和功能方面的异质性。在这篇综述中，我们将讨论微生物群对粒细胞生成和随后的中性粒细胞在癌症中的活性的影响。随着这一微生物群-中性粒细胞-癌症轴的证据不断积累，它为改善癌症患者的预后提供了新的治疗靶点。
