Parravicini C L, Vago L, Costanzi G C, Gluckman J C, Klatzmann D, Berti E, Barre-Sinoussi F, Chermann J C, Lazzarin A, Moroni M
Boll Ist Sieroter Milan. 1985;64(5):422-4.
This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.
本研究涉及一种针对LAV病毒p18蛋白产生的单克隆抗体（Mab）的免疫组织化学，研究对象为20例持续性全身性淋巴结病（PGL）（2）患者和6例获得性免疫缺陷综合征（AIDS）（3）患者的淋巴结。在所有已研究的PGL病例中，我们观察到生发中心滤泡树突状细胞（FDC）框架受到非常严重的破坏，这与生发中心内Leu2a +淋巴细胞数量增加有关。这一观察结果与PGL综合征淋巴结的主要形态学特征一致，该综合征主要以FD细胞病变为特征。
