Farndale R W, Murray J C
Biochim Biophys Acta. 1986 Mar 19;881(1):46-53. doi: 10.1016/0304-4165(86)90095-4.
Pulsed magnetic fields, similar to those used clinically to promote bone repair, have been applied to cultured fibroblasts obtained from chick embryo tendons and rabbit bone marrow. Cyclic adenosine monophosphate (cAMP) levels were found to be lower in field-treated cultures in response to hormones such as prostaglandin E2 and isoproterenol, and the fibroblasts appear less sensitive to environmental perturbation prior to hormone incubation. We propose that the adenylate cyclase complex is temporarily inactivated by prolonged exposure to pulsed magnetic fields, and that this effect might be analogous to desensitisation phenomena.
与临床上用于促进骨修复的脉冲磁场类似的磁场，已被应用于从鸡胚肌腱和兔骨髓中获取的培养成纤维细胞。发现在脉冲磁场处理过的培养物中，环磷酸腺苷（cAMP）水平对诸如前列腺素E2和异丙肾上腺素等激素的反应较低，并且在激素孵育之前，成纤维细胞对环境扰动的敏感性似乎较低。我们认为，腺苷酸环化酶复合物因长时间暴露于脉冲磁场而暂时失活，并且这种效应可能类似于脱敏现象。
