Kalin N H
Biol Psychiatry. 1986 Feb;21(2):124-40. doi: 10.1016/0006-3223(86)90140-x.
Adrenocorticotrophic hormone (ACTH) and other biosynthetically related peptides are found both in the brain and peripherally, but the function and regulation of these substances differ in the brain and in the periphery. It has been suggested that measurement of peptide hormones in the cerebrospinal fluid (CSF) might provide information relevant to the diagnosis and pathophysiology of neurological and psychiatric illnesses. We report experiments using a rhesus monkey model to evaluate parameters affecting CSF ACTH concentrations. We found that CSF ACTH concentrations follow a diurnal rhythm that is markedly different from that in plasma, concentrations of ACTH in monkey CSF, but not in plasma, increased significantly after 4 days of social separation, and CSF ACTH concentrations did not change after hypophysectomy. These results suggest that CSF ACTH concentrations reflect the activity of brain and not peripheral ACTH systems.
促肾上腺皮质激素（ACTH）以及其他生物合成相关肽在脑内和外周均有发现，但这些物质在脑内和外周的功能及调节有所不同。有人提出，测量脑脊液（CSF）中的肽类激素可能为神经和精神疾病的诊断及病理生理学提供相关信息。我们报告了使用恒河猴模型进行的实验，以评估影响脑脊液促肾上腺皮质激素浓度的参数。我们发现，脑脊液促肾上腺皮质激素浓度呈现出与血浆中明显不同的昼夜节律，恒河猴脑脊液中的促肾上腺皮质激素浓度在社会隔离4天后显著升高，而血浆中的浓度则未升高，并且垂体切除术后脑脊液促肾上腺皮质激素浓度没有变化。这些结果表明，脑脊液促肾上腺皮质激素浓度反映的是脑的活性，而非外周促肾上腺皮质激素系统的活性。
