Kalin N H, Shelton S E, Barksdale C M, Carnes M
Life Sci. 1985 Mar 25;36(12):1135-40. doi: 10.1016/0024-3205(85)90229-2.
ACTH immunoreactivity (ACTH-IR) in the plasma and cerebrospinal fluid (CSF) collected simultaneously from rhesus monkeys was found to undergo significant diurnal variations. In plasma, the mean peak ACTH-IR was 15.4 +/- 1.95 pg/ml at 0500 h, and the mean minimum concentration was 9.05 +/- 1.80 pg/ml at 1800 h. In CSF, the mean peak ACTH-IR concentration occurred at 1900 h and was 4.64 +/- 0.41 pg/ml. The mean minimum CSF ACTH-IR concentration was 2.93 +/- 0.26 pg/ml, occurring at 0500 h. This is the first report of a diurnal variation in CSF ACTH-IR concentration and is consistent with other work suggesting that plasma ACTH and CSF ACTH originate from different sources.
在同时从恒河猴采集的血浆和脑脊液（CSF）中发现，促肾上腺皮质激素免疫反应性（ACTH-IR）呈现显著的昼夜变化。在血浆中，ACTH-IR的平均峰值在05:00时为15.4±1.95 pg/ml，平均最低浓度在18:00时为9.05±1.80 pg/ml。在脑脊液中，ACTH-IR浓度的平均峰值出现在19:00时，为4.64±0.41 pg/ml。脑脊液ACTH-IR的平均最低浓度为2.93±0.26 pg/ml，出现在05:00时。这是关于脑脊液ACTH-IR浓度昼夜变化的首次报告，并且与其他表明血浆ACTH和脑脊液ACTH来源不同的研究结果一致。
