Thomas-Morvan C
C R Acad Sci III. 1985;301(10):487-90.
In primary cultures of cells from human thyroid cancer, functional activity was investigated by adenylate cyclase responsiveness and radioiodine uptake. In cells from well-differentiated follicular carcinomas (2 cases), TSH stimulation of cAMP accumulation is similar to that of normal thyroid cells. In contrast, in papillary carcinomas (11 cases), the mean dose-response curve is much lower than normal. In thyroid cancers, radioiodine uptake by the cells has been detected in some cases after 3 days of 125I incorporation. As previously observed, our results suggest the existence of a relationship between adenylcyclase responsiveness and 125I uptake by the cells.
在人甲状腺癌细胞的原代培养中，通过腺苷酸环化酶反应性和放射性碘摄取来研究功能活性。在来自高分化滤泡癌（2例）的细胞中，促甲状腺激素（TSH）刺激的环磷酸腺苷（cAMP）积累与正常甲状腺细胞相似。相比之下，在乳头状癌（11例）中，平均剂量反应曲线远低于正常水平。在甲状腺癌中，部分病例在加入125I 3天后检测到细胞对放射性碘的摄取。如先前观察到的，我们的结果表明腺苷酸环化酶反应性与细胞对125I的摄取之间存在关联。
