Morrison D K, Moyer R W
Cell. 1986 Feb 28;44(4):587-96. doi: 10.1016/0092-8674(86)90268-0.
A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Following RPV infection, the Pol II subunit is translocated from the nucleus to the cytoplasmic virosomes, then packaged into mature virus, and is found associated with the viral RNA polymerase purified from virions. The results suggest that the cellular Pol II subunit may be directly involved in the transcription of viral genes.
细胞RNA聚合酶II（Pol II）的一个大亚基（约200kd）与兔痘病毒（RPV）RNA聚合酶的一个病毒编码亚基（137kd）能与共同的单克隆抗体发生反应。对病毒和细胞DNA克隆进行的杂交研究证实，病毒蛋白和细胞蛋白具有相关性。在RPV感染后，Pol II亚基从细胞核转位至细胞质病毒体，随后被包装进成熟病毒中，并发现其与从病毒粒子中纯化出的病毒RNA聚合酶相关联。这些结果表明，细胞Pol II亚基可能直接参与病毒基因的转录。
