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非病毒蛋白与重组痘苗病毒病毒粒子的关联。

Association of non-viral proteins with recombinant vaccinia virus virions.

作者信息

Franke C A, Hruby D E

出版信息

Arch Virol. 1987;94(3-4):347-51. doi: 10.1007/BF01310729.

DOI:10.1007/BF01310729
PMID:3472503
Abstract

Evidence is presented which suggests that recombinant vaccinia virus particles (VV:CAT), containing the bacterial chloramphenicol acetyl transferase gene, are capable of encapsidating both the foreign protein which they encode (CAT) as well as cellular enzymes such as thymidine kinase. These results are discussed with respect to using VV to passively introduce biologically-active proteins into cells or organisms.

摘要

有证据表明，含有细菌氯霉素乙酰转移酶基因的重组痘苗病毒颗粒（VV:CAT）能够包裹它们所编码的外源蛋白（CAT）以及细胞酶，如胸苷激酶。就利用痘苗病毒将生物活性蛋白被动导入细胞或生物体这一点对这些结果进行了讨论。

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3
Cell-free translation of a chimeric eucaryotic-procaryotic message yields functional chloramphenicol acetyltransferase.
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本文引用的文献

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Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase.无细胞合成具有酶活性的痘苗病毒胸苷激酶。
Virology. 1981 Sep;113(2):594-601. doi: 10.1016/0042-6822(81)90187-2.
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Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.在哺乳动物细胞中表达氯霉素乙酰转移酶的重组基因组。
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Inhibition of HeLa cell protein synthesis by the vaccinia virion.牛痘病毒粒子对HeLa细胞蛋白质合成的抑制作用。
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Vaccinia virus recombinants expressing an 11-kilodalton beta-galactosidase fusion protein incorporate active beta-galactosidase in virus particles.表达11千道尔顿β-半乳糖苷酶融合蛋白的痘苗病毒重组体在病毒颗粒中掺入了活性β-半乳糖苷酶。
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Vaccinia virus vectors: new strategies for producing recombinant vaccines.痘苗病毒载体：生产重组疫苗的新策略。
Clin Microbiol Rev. 1990 Apr;3(2):153-70. doi: 10.1128/CMR.3.2.153.
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Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions.通过重组痘苗病毒表达辛德毕斯病毒结构蛋白：合成、加工及整合到成熟的辛德毕斯病毒粒子中。
J Virol. 1985 Oct;56(1):227-39. doi: 10.1128/JVI.56.1.227-239.1985.
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In vitro mutagenesis of the promoter region for a vaccinia virus gene: evidence for tandem early and late regulatory signals.痘苗病毒基因启动子区域的体外诱变：串联早期和晚期调控信号的证据。
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Recombinant vaccinia viruses as vaccines.作为疫苗的重组痘苗病毒。
Nature. 1986;319(6054):549-50. doi: 10.1038/319549a0.
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Live recombinant vaccines using genetically engineered vaccinia virus.使用基因工程痘苗病毒的活重组疫苗。
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Expression and cell type--specific processing of human preproenkephalin with a vaccinia recombinant.人前脑啡肽原在痘苗重组体中的表达及细胞类型特异性加工
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Cell. 1986 Feb 28;44(4):587-96. doi: 10.1016/0092-8674(86)90268-0.
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Transcription of vaccinia virus early genes by a template-dependent soluble extract of purified virions.利用纯化病毒粒子的模板依赖性可溶性提取物转录痘苗病毒早期基因。
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