内源性催产素在焦虑缓解中的作用：结构和功能相关性。
The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates.
机构信息
University of Virginia, Charlottesville, Virginia.
The Kinsey Institute, Indiana University, Bloomington, Indiana.
出版信息
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):618-625. doi: 10.1016/j.bpsc.2017.10.003. Epub 2017 Oct 24.
BACKGROUND
Oxytocin is anxiolytic, and administration of synthetic oxytocin in humans reduces amygdala reactivity to negative stimuli. However, it is unknown whether endogenous oxytocin levels-which are heritable and stable across time-attenuate anxiety via similar mechanisms.
METHODS
In this study, we used plasma assays and structural and functional neuroimaging to examine potential anxiolytic effects of endogenous oxytocin in 73 participants.
RESULTS
We found that higher endogenous oxytocin levels are associated with reduced central amygdala volume and blood oxygen level-dependent activity in response to aversive stimuli. In contrast to previous reports, we found that oxytocin was not related to patterns of functional connectivity between the amygdala and other brain regions.
CONCLUSIONS
Together, our results underscore the importance of considering individual differences in participants' endogenous oxytocin with respect to anxiety-related neural activity and neuromorphology.
背景
催产素具有抗焦虑作用，给人类施用合成催产素会降低杏仁核对负面刺激的反应。然而，目前尚不清楚内源性催产素水平——其具有遗传性且在时间上保持稳定——是否通过类似的机制减轻焦虑。
方法
在这项研究中，我们使用血浆检测和结构及功能神经影像学技术，检查了 73 名参与者内源性催产素的潜在抗焦虑作用。
结果
我们发现，较高的内源性催产素水平与对厌恶刺激的中央杏仁核体积和血氧水平依赖活动减少有关。与之前的报告不同，我们发现催产素与杏仁核与其他大脑区域之间的功能连接模式无关。
结论
总之，我们的研究结果强调了在考虑与焦虑相关的神经活动和神经形态学时，需要考虑参与者内源性催产素的个体差异。
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