Gabrilove J L, Krakoff L R
Compr Ther. 1986 Jan;12(1):17-21.
Cushing's syndrome is the consequence of a sustained overproduction of cortisol (hydrocortisone) by the adrenal cortex. This may be due to excessive secretion of cortisol by functioning adrenocortical tumors or to "nontumorous" adrenocortical hyperfunction. The latter may be a result of stimulation of the adrenal cortex by increased release of corticotropin (ACTH) from a small pituitary tumor or from nonpituitary nonadrenal tumor. Carcinoids or carcinomas of the lung or pancreas, and even pheochromocytomas have caused the syndrome of ectopic ACTH production. The problems involved in the diagnosis of Cushing's syndrome are establishing its presence and determining the underlying cause. Treatment is then dependent upon the underlying pathogenetic lesion.
库欣综合征是肾上腺皮质持续过度分泌皮质醇（氢化可的松）的结果。这可能是由于功能性肾上腺皮质肿瘤过度分泌皮质醇，或由于“非肿瘤性”肾上腺皮质功能亢进。后者可能是由于垂体小肿瘤或非垂体非肾上腺肿瘤释放促肾上腺皮质激素（ACTH）增加，刺激肾上腺皮质所致。肺癌或胰腺癌的类癌或癌，甚至嗜铬细胞瘤都可引起异位ACTH分泌综合征。库欣综合征诊断中涉及的问题是确定其存在并找出潜在病因。然后根据潜在的致病病变进行治疗。
