Department of Intensive Care, UMC Utrecht, Utrecht, The Netherlands; Department of Radiology, UMC Utrecht, Utrecht, The Netherlands.
Department of Radiology, UMC Utrecht, Utrecht, The Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Neurobiol Aging. 2018 Oct;70:247-253. doi: 10.1016/j.neurobiolaging.2018.06.032. Epub 2018 Jun 30.
Physical frailty is an age-associated syndrome of decreased reserve leading to vulnerability to physiological stressors and associated with negative outcomes. The underlying structural brain abnormalities of physical frailty are unclear. We investigated the association between brain volume, cortical brain infarcts, and physical frailty. In this multicenter study, 214 nondemented participants were classified as frail (n = 32), prefrail (n = 107), or nonfrail (n = 75) based on the Fried frailty phenotype. The associations between frailty and brain volumes and cortical brain infarcts were investigated by linear or logistic regression analyses. Participants in the frail group showed a lower total brain volume (-19.67 mL [95% confidence interval -37.84 to -1.50]) and lower gray matter volume (-12.19 mL [95% confidence interval -23.84 to -0.54]) compared to nonfrail participants. Frailty was associated with cortical brain infarcts [frail 16% [n = 5], prefrail 11% [n = 12], and nonfrail 3% [n = 2]). Reduced total brain volume and gray matter volume and increased cortical brain infarcts seem therefore to be part of the structural substrate of the physical frailty phenotype.
身体虚弱是一种与年龄相关的储备能力下降综合征，导致对生理应激源的脆弱性，并与不良后果相关。身体虚弱的潜在结构性大脑异常尚不清楚。我们研究了大脑体积、皮质脑梗死与身体虚弱之间的关系。在这项多中心研究中，214 名非痴呆参与者根据 Fried 虚弱表型分为虚弱组（n=32）、虚弱前期组（n=107）或非虚弱组（n=75）。通过线性或逻辑回归分析研究了虚弱与大脑体积和皮质脑梗死之间的关系。与非虚弱组相比，虚弱组的总脑体积较低（-19.67 毫升[95%置信区间-37.84 至-1.50]）和灰质体积较低（-12.19 毫升[95%置信区间-23.84 至-0.54]）。虚弱与皮质脑梗死有关[虚弱 16%（n=5），虚弱前期 11%（n=12），非虚弱 3%（n=2）]。因此，总脑体积和灰质体积减少以及皮质脑梗死增加似乎是身体虚弱表型的结构性基础的一部分。
