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同一机构同一急性外科服务科室接受相似手术的患者之间阿片类药物处方模式的变化:是否需要标准化?

Variation of Opioid Prescribing Patterns among Patients undergoing Similar Surgery on the Same Acute Care Surgery Service of the Same Institution: Time for Standardization?

机构信息

Division of Trauma, Emergency Surgery & Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School.

Division of Trauma, Emergency Surgery & Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School.

出版信息

Surgery. 2018 Nov;164(5):926-930. doi: 10.1016/j.surg.2018.05.047. Epub 2018 Jul 23.

DOI:10.1016/j.surg.2018.05.047
PMID:30049481
Abstract

BACKGROUND

Diversion of unused prescription opioids is a major contributor to the current United States opioid epidemic. We aimed to study the variation of opioid prescribing in emergency surgery.

METHODS

Between October 2016 and March 2017, all patients undergoing laparoscopic appendectomy, laparoscopic cholecystectomy, or inguinal hernia repair in the acute care surgery service of 1 academic center were included. For each patient, we systematically reviewed the electronic medical record and the prescribing pharmacy platform to identify: (1) history of opioid abuse, (2) opioid intake 3 months preoperatively, (3) number of opioid pills prescribed, (4) prescription of nonopioid pain medications (eg, acetaminophen, ibuprofen), and (5) the need for opioid prescription refills. The mean and range of opioid pills prescribed, as well as their oral morphine equivalent, were calculated.

RESULTS

A total of 255 patients were included (43.5% laparoscopic appendectomy, 44.3% laparoscopic cholecystectomy, and 12.1% inguinal hernia repair). The mean age was 47.5 years, 52.1% were female, 11.4% had a history of opioid use, and 92.5% received opioid prescriptions upon hospital discharge. Only 70.9% of patients were instructed to use nonopioid pain medications. The mean and range of opioid pills prescribed were 17.4; 0-56 (laparoscopic appendectomy), 17.1; 0-75 (laparoscopic cholecystectomy), and 20.9; 0-50 (inguinal hernia repair), while the range of prescribed oral morphine equivalent was 0-600 mg for laparoscopic appendectomy/laparoscopic cholecystectomy and 0-375 mg for inguinal hernia repair. No patients required any opioid medication refills.

CONCLUSION

Even within the same surgical service, wide variation of opioid prescription was observed. Guidelines that standardize pain management may help prevent opioid overprescribing.

摘要

背景

未使用的处方类阿片类药物的转移是美国当前阿片类药物流行的一个主要原因。我们旨在研究急诊手术中阿片类药物处方的变化。

方法

在 2016 年 10 月至 2017 年 3 月期间,1 个学术中心的急症外科服务中的所有接受腹腔镜阑尾切除术、腹腔镜胆囊切除术或腹股沟疝修补术的患者均纳入研究。对于每位患者,我们系统地查阅了电子病历和处方配药平台,以确定:(1)阿片类药物滥用史;(2)术前 3 个月的阿片类药物摄入情况;(3)开具的阿片类药物丸数;(4)非阿片类止痛药(如对乙酰氨基酚、布洛芬)的处方情况;(5)阿片类药物处方续开的需求。计算开具的阿片类药物丸数的均值和范围,以及其口服吗啡等效值。

结果

共纳入 255 例患者(43.5%为腹腔镜阑尾切除术,44.3%为腹腔镜胆囊切除术,12.1%为腹股沟疝修补术)。平均年龄为 47.5 岁,52.1%为女性,11.4%有阿片类药物使用史,92.5%的患者在出院时开具了阿片类药物处方。只有 70.9%的患者被指示使用非阿片类止痛药。开具的阿片类药物丸数的均值和范围为 17.4;0-56(腹腔镜阑尾切除术)、17.1;0-75(腹腔镜胆囊切除术)和 20.9;0-50(腹股沟疝修补术),而开具的口服吗啡等效值范围为 0-600mg 用于腹腔镜阑尾切除术/腹腔镜胆囊切除术和 0-375mg 用于腹股沟疝修补术。没有患者需要任何阿片类药物续开。

结论

即使在同一外科服务中,也观察到阿片类药物处方的广泛差异。标准化疼痛管理的指南可能有助于防止阿片类药物的过度处方。

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