Department of Surgery, Surgical Outcomes Program, Mayo Clinic, Rochester, MN.
The Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
Surgery. 2019 Nov;166(5):752-757. doi: 10.1016/j.surg.2019.05.012. Epub 2019 Jun 20.
Open inguinal hernia repair is thought to cause worse postoperative pain than minimally invasive surgery, and thus patients are often prescribed more opioids at discharge. This study evaluates opioid use in inguinal hernia repair patients to optimize discharge prescribing practices for this common procedure.
Opioid-naive adults undergoing open or minimally invasive surgery inguinal hernia repair were identified prospectively from 3 centers to complete a 29-question telephone interview after discharge as part of a larger initiative. Opioid prescription and consumption data were converted into morphine milligram equivalents and compared between minimally invasive surgery and open inguinal hernia repair. Univariate χ, Fisher exact test, univariate, and multivariable logistic regression were used.
Of 249 contacted patients, 195 (74%) completed the survey (n = 97 open, n = 98 minimally invasive surgery). Patients undergoing open inguinal hernia repair were slightly older (71 vs 65 years, P < .001) and less likely to be female (3% vs 17%, P = .001) than minimally invasive surgery patients. Open patients were more likely to have a unilateral inguinal hernia repair (95% open vs 52% minimally invasive surgery, P < .001). Discharge pain scores using the 10-point, patient-reported Numeric Pain Rating scale were similar (open 2.3 ± 1.7 vs minimally invasive surgery 2.4 ± 1.6; P = .80), and most patients were satisfied with postoperative pain control (open 86% vs minimally invasive surgery 95%; P = .13). Open inguinal hernia repair patients were just as likely to receive opioids at discharge as those undergoing minimally invasive surgery inguinal hernia repair (98% vs 91% minimally invasive surgery; P = .06) and were prescribed similar amounts of opioids (open 155 [IQR 113, 225] morphine milligram equivalents vs 150 [IQR 100, 210] minimally invasive surgery; P = .08). There was no difference in opioid use by approach (open 15 [IQR 0, 60] morphine milligram equivalents vs 9 [IQR 0, 50] minimally invasive surgery; P = .33). More than one-third of patients used no opioids (open 38% vs minimally invasive surgery 44%; P = .42). Bilateral repair was not associated with increased opioid use (univariate odds ratio 1.23, P = .58). On multivariable analysis, low discharge pain and normal body mass index were independently associated with needing no opioids at discharge. Overall, 75% of prescribed opioids remained unused at time of survey, yet only 12% of patients had disposed of unused opioids at the time of survey.
Postdischarge opioid utilization was clinically similar between patients undergoing open and minimally invasive surgery inguinal hernia repair and those requiring unilateral or bilateral repair. Given that more than one-third of patients required no opioids after discharge, 0 to 8 tablets of 5 mg oxycodone is sufficient for most opioid-naive patients undergoing inguinal hernia repair.
开放式腹股沟疝修补术被认为比微创手术引起更严重的术后疼痛,因此患者通常在出院时被开具更多的阿片类药物。本研究评估了腹股沟疝修补术患者的阿片类药物使用情况,以优化这种常见手术的出院处方实践。
前瞻性地从 3 个中心确定接受开放式或微创手术腹股沟疝修补术的阿片类药物初治成人,作为更大规模计划的一部分,在出院后完成 29 个问题的电话访谈。将阿片类药物处方和使用数据转换为吗啡毫克当量,并在微创手术和开放式腹股沟疝修补术之间进行比较。使用单变量 χ 2 检验、Fisher 确切检验、单变量和多变量逻辑回归。
在联系的 249 名患者中,195 名(74%)完成了调查(n=97 例开放式,n=98 例微创手术)。接受开放式腹股沟疝修补术的患者年龄稍大(71 岁比 65 岁,P<0.001),女性比例较低(3%比 17%,P=0.001)。开放式手术患者更可能接受单侧腹股沟疝修补术(95%的开放式手术比 52%的微创手术,P<0.001)。使用 10 分患者报告数字疼痛评分量表评估的出院疼痛评分相似(开放式 2.3±1.7 与微创手术 2.4±1.6;P=0.80),大多数患者对术后疼痛控制满意(开放式 86%与微创手术 95%;P=0.13)。接受开放式腹股沟疝修补术的患者与接受微创手术腹股沟疝修补术的患者一样,出院时同样有可能接受阿片类药物治疗(98%比微创手术 91%;P=0.06),并且开具的阿片类药物剂量相似(开放式 155[IQR 113, 225]吗啡毫克当量与微创手术 150[IQR 100, 210];P=0.08)。手术方法(开放式 15[IQR 0, 60]吗啡毫克当量与微创手术 9[IQR 0, 50];P=0.33)与阿片类药物使用无关。超过三分之一的患者未使用阿片类药物(开放式 38%与微创手术 44%;P=0.42)。双侧修复与增加阿片类药物使用无关(单变量比值比 1.23,P=0.58)。多变量分析显示,出院时疼痛较轻和正常体重指数与不需要出院时使用阿片类药物独立相关。总体而言,75%的处方阿片类药物在调查时未使用,但只有 12%的患者在调查时已处理未使用的阿片类药物。
接受开放式和微创手术腹股沟疝修补术以及需要单侧或双侧修复的患者出院后阿片类药物的使用情况在临床上相似。鉴于超过三分之一的患者在出院后不需要阿片类药物,大多数接受腹股沟疝修补术的阿片类药物初治患者需要 0 至 8 片 5 毫克羟考酮即可。