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常规与困难胆囊切除术:应用预测分析评估患者结局。

Routine versus difficult cholecystectomy: using predictive analytics to assess patient outcomes.

机构信息

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, Carolinas Medical Center, Charlotte, NC, USA.

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, Carolinas Medical Center, Charlotte, NC, USA.

出版信息

HPB (Oxford). 2019 Jan;21(1):77-86. doi: 10.1016/j.hpb.2018.06.1805. Epub 2018 Jul 24.

Abstract

BACKGROUND

The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Surgical Risk. Calculator (SRC) estimates postoperative outcomes. The aim of this study was to develop and validate a specific predictive outcomes model for cholecystectomy procedures.

METHODS

Patients who underwent cholecystectomy between 2008 and 2016 and were deemed too high risk for acute care general surgery (GS) and had surgery performed by the Division of Hepatopancreatobiliary Surgery (HPB) were identified. Outcomes of the HPB cholecystectomies were matched against cholecystectomies performed by GS. New predictive models for postoperative outcomes were constructed. Area under the curve was used to assess predictive accuracy for both models and internal validation was performed using bootstrap logistic regression.

RESULTS

A total of 169/934 (18%) cholecystectomies were identified as too high risk for GS. These 169 patients were matched with 126 patients who had cholecystectomy performed by GS. For GS and HPB cholecystectomies, the proposed model demonstrated better discriminative ability compared to the SRC based on ROC curves (proposed model: 0.589-0.982; SRC: 0.570-0.836) for each of the predicted outcomes.

CONCLUSION

For patients undergoing cholecystectomy, customized models are superior for predicting individual perioperative risk and allow more accurate, patient-specific delivery of care.

摘要

背景

美国外科医师学院国家外科质量改进计划(NSQIP)手术风险计算器(SRC)可预测术后结果。本研究旨在开发和验证一种专门用于预测胆囊切除术结果的预测模型。

方法

我们确定了 2008 年至 2016 年间接受胆囊切除术且被认为不适合接受急性普通外科(GS)治疗的高危患者,并由肝胆胰外科(HPB)进行手术。将 HPB 胆囊切除术的结果与 GS 进行的胆囊切除术的结果进行匹配。建立新的预测模型来评估术后结果。曲线下面积(AUC)用于评估两种模型的预测准确性,并使用 bootstrap 逻辑回归进行内部验证。

结果

共有 169/934(18%)例胆囊切除术被认为不适合 GS。这 169 例患者与 126 例由 GS 进行胆囊切除术的患者进行了匹配。对于 GS 和 HPB 胆囊切除术,与基于 SRC 的 ROC 曲线相比,所提出的模型在预测每种结果时具有更好的判别能力(提出的模型:0.589-0.982;SRC:0.570-0.836)。

结论

对于接受胆囊切除术的患者,定制模型在预测个体围手术期风险方面具有优势,可以更准确地提供个性化的护理。

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