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急危重症普通外科手术后 30 天结局比较:具有针对性改进的潜力。

Comparison of 30-day outcomes after emergency general surgery procedures: potential for targeted improvement.

机构信息

Division of Research and Optimal Patient Care, American College of Surgeons, Chicago, IL 60611, USA.

出版信息

Surgery. 2010 Aug;148(2):217-38. doi: 10.1016/j.surg.2010.05.009.

Abstract

BACKGROUND

Patients who undergo emergency operations represent a high-risk population and have been shown to have a high risk of poor outcomes. Little is known, however, about the variability in the quality of emergency general surgical care across hospitals or within hospitals across different procedures. The objectives of this study were to identify risk factors associated with adverse events, to compare 30-day outcomes after 3 common emergency general surgery procedures within and across hospitals, and thus, to determine whether the quality of emergency surgical care is procedure-dependent or intrinsic to other aspects of the hospital environment.

METHODS

Patients who underwent emergency appendectomy, cholecystectomy, or colorectal resection at 95 hospitals that submitted at least 20 of each procedure were identified in the 2005-2008 American College of Surgeons National Surgical Quality Improvement Project database. Outcomes of interest included 30-day overall morbidity and serious morbidity/mortality. Step-wise logistic regression generated patient-level predicted probabilities of an outcome. Based on the expected probabilities, observed to expected (O/E) ratios for each outcome, after each of the 3 procedures, were calculated for each hospital. Hospitals were divided into terciles based on O/E ratios. The agreement on hospital outcomes performance for overall morbidity and serious morbidity/mortality after appendectomy, cholecystectomy, and colorectal resection was assessed using weighted kappa statistics.

RESULTS

Of the 30,788 appendectomies, 1,984 (6.44%) patients had any morbidity, and 1,140 (3.70%) patients had a serious morbidity or died. Of the 5,824 cholecystectomies, 503 (8.64%) patients had any morbidity, and 371 (6.37%) patients had a serious morbidity or died. Of the 8,990 colorectal resections, 4,202 (46.74%) patients had any morbidity, and 3,736 (41.56%) patients had a serious morbidity or died. For overall morbidity, O/E ratios for appendectomy ranged from 0.26 to 2.36; O/E ratios for cholecystectomy ranged from 0 to 3.04; O/E ratios for colorectal resection ranged from 0.45 to 1.51. For serious morbidity/mortality, O/E ratios for appendectomy ranged from 0.23 to 2.54; O/E ratios for cholecystectomy ranged from 0 to 4.28; O/E ratios for colorectal resection ranged from 0.59 to 1.75. Associations of risk-adjusted hospital outcomes based on tercile rank between procedures demonstrated slight but significant agreement for both overall morbidity (weighted kappa between 0.20 and 0.22) and serious morbidity/mortality (weighted kappa between 0.18 and 0.22). Despite this, 7 (7.4%) hospitals for overall morbidity and 9 (9.5%) hospitals for serious morbidity/mortality were rated in the highest (best) tercile for all procedures. Eight (8.4%) hospitals for overall morbidity and 8 (8.4%) hospitals for serious morbidity/mortality were rated in the lowest tercile for all procedures.

CONCLUSION

Emergency general surgery procedures, particularly colorectal resections, were associated with substantial 30-day overall morbidity and serious morbidity/mortality. Most hospitals did not have consistent risk-adjusted outcomes across all 3 procedures, but for a substantive minority of institutions (7-10%), good or bad performance was generalizable across procedures. Individual hospitals should examine their procedure-specific outcomes after emergency general surgery operations to focus quality improvement initiatives appropriately.

摘要

背景

接受急诊手术的患者属于高危人群,其不良预后的风险较高。然而,人们对医院之间或同一医院不同手术之间的普通急诊外科护理质量的差异知之甚少。本研究的目的是确定与不良事件相关的风险因素,比较 3 种常见的普通急诊外科手术后 30 天的结果,并确定急诊外科护理质量是取决于手术本身还是取决于医院环境的其他方面。

方法

在美国外科医师学院国家外科质量改进计划数据库中,确定了 95 家医院在 2005-2008 年期间至少各进行了 20 例阑尾切除术、胆囊切除术或结直肠切除术的患者。感兴趣的结果包括 30 天整体发病率和严重发病率/死亡率。逐步逻辑回归生成患者结局的预测概率。根据预期概率,计算了每所医院在每一种手术之后的观察到的与预期的(O/E)比值。根据 O/E 比值,将医院分为 3 个三分位数组。使用加权 Kappa 统计评估阑尾切除术、胆囊切除术和结直肠切除术整体发病率和严重发病率/死亡率的医院结局表现的一致性。

结果

在 30788 例阑尾切除术中,1984 例(6.44%)患者有任何发病率,1140 例(3.70%)患者有严重发病率或死亡。在 5824 例胆囊切除术中,503 例(8.64%)患者有任何发病率,371 例(6.37%)患者有严重发病率或死亡。在 8990 例结直肠切除术中,4202 例(46.74%)患者有任何发病率,3736 例(41.56%)患者有严重发病率或死亡。对于整体发病率,阑尾切除术的 O/E 比值范围为 0.26 至 2.36;胆囊切除术的 O/E 比值范围为 0 至 3.04;结直肠切除术的 O/E 比值范围为 0.45 至 1.51。对于严重发病率/死亡率,阑尾切除术的 O/E 比值范围为 0.23 至 2.54;胆囊切除术的 O/E 比值范围为 0 至 4.28;结直肠切除术的 O/E 比值范围为 0.59 至 1.75。基于三分位数等级的风险调整后医院结局的关联表明,整体发病率(加权 Kappa 值在 0.20 到 0.22 之间)和严重发病率/死亡率(加权 Kappa 值在 0.18 到 0.22 之间)之间存在轻微但显著的一致性。尽管如此,7 家(7.4%)医院的整体发病率和 9 家(9.5%)医院的严重发病率/死亡率在所有手术中被评为最高(最佳)三分位数。8 家(8.4%)医院的整体发病率和 8 家(8.4%)医院的严重发病率/死亡率在所有手术中被评为最低三分位数。

结论

普通急诊外科手术,特别是结直肠切除术,与 30 天整体发病率和严重发病率/死亡率有显著相关性。大多数医院在所有 3 种手术中没有一致的风险调整后结局,但对于相当一部分机构(7-10%),良好或不良的表现可以跨手术推广。个别医院应检查其普通急诊外科手术后的特定手术结局,以便有针对性地进行质量改进。

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