Bladen John Christopher, Gill Jasdeep Singh, Miszkiel Katherine, Ezra Daniel George
Department of Oculoplastics, Moorfields Eye Hospital, London, UK.
Development, Ageing and Disease, UCL Institute of Ophthalmology, London, UK.
BMJ Case Rep. 2018 Jul 25;2018:bcr-2018-224339. doi: 10.1136/bcr-2018-224339.
Primary blepharospasm is an adult-onset focal dystonia characterised by involuntary contractions of the orbicularis oculi, leading to bilateral spasmodic closure of the eyelids. While spasms of this muscle constitute the hallmark of disease, other motor manifestations include increased spontaneous blinking and apraxia of eyelid opening. Originally misdiagnosed as a psychiatric condition, blepharospasm is now well established as being of neurological origin although questions remain as to its pathophysiological mechanisms.We report a 66-year-old woman who had a 14-year history of primary blepharospasm which completely resolved following a left medial cerebral artery thromboembolic infarct of the lenticular nucleus. This report provides supporting evidence of the lenticular nucleus as a key structure mediating the disease which can lead to functional blindness.
原发性睑痉挛是一种成人起病的局灶性肌张力障碍，其特征为眼轮匝肌不自主收缩，导致双侧眼睑痉挛性闭合。虽然该肌肉的痉挛是疾病的标志，但其他运动表现还包括自发性眨眼增加和眼睑开合失用症。睑痉挛最初被误诊为精神疾病，现在已明确其起源于神经学，尽管其病理生理机制仍存在疑问。我们报告一名66岁女性，她有14年原发性睑痉挛病史，在左侧大脑中动脉血栓栓塞性梗死累及豆状核后，睑痉挛完全缓解。本报告为豆状核作为介导该疾病的关键结构提供了支持性证据，该疾病可导致功能性失明。
