Ma Chiyuan, Zhou Xiaopeng, Xu Kai, Wang Linyan, Yang Yute, Wang Wei, Liu An, Ran Jisheng, Yan Shigui, Wu Haobo, Wu Lidong
Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Ophthalmology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Pharmacol. 2018 Jun 28;9:700. doi: 10.3389/fphar.2018.00700. eCollection 2018.
As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism were studied and The results showed that SPN decreases the expression of cartilage matrix-degrading enzymes and the activation of NF-κB and wnt/β-catenin signaling, and increases chondrocyte-specific gene expression in IL-1β-induced inflammation in chondrocytes. Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.
骨关节炎（OA）作为一种慢性疾病，会导致软骨和软骨下骨的退化，其发展由白细胞介素-1β等促炎细胞因子介导。在本研究中，研究了筋骨草内酯（SPN）在骨关节炎中的抗炎作用及其潜在机制，结果表明，SPN可降低软骨基质降解酶的表达以及NF-κB和wnt/β-连环蛋白信号通路的激活，并增加白细胞介素-1β诱导的软骨细胞炎症中软骨细胞特异性基因的表达。此外，SPN治疗可预防骨关节炎大鼠模型中软骨和软骨下骨的退化。据我们所知，本研究首次报道SPN通过抑制NF-κB和wnt/β-连环蛋白通路的激活来减轻白细胞介素-1β诱导的大鼠软骨细胞炎症，因此，在骨关节炎治疗中具有治疗潜力。
