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Cortical stress regulation is disrupted in schizophrenia but not in clinical high risk for psychosis.精神分裂症患者皮质应激调节紊乱，但精神病高危临床患者无此现象。
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Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis.移民及其子女纹状体多巴胺功能增强：一种精神病的风险机制。
Schizophr Bull. 2017 Mar 1;43(2):293-301. doi: 10.1093/schbul/sbw181.
3
Prefrontal Cortex Dysfunction Increases Susceptibility to Schizophrenia-Like Changes Induced by Adolescent Stress Exposure.前额叶皮质功能障碍会增加青少年应激暴露所诱发的类似精神分裂症变化的易感性。
Schizophr Bull. 2017 May 1;43(3):592-600. doi: 10.1093/schbul/sbw156.
4
Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine D Receptor Upregulation.来自多巴胺D受体上调小鼠模型的关于纹状体回路功能与精神分裂症的见解。
Biol Psychiatry. 2017 Jan 1;81(1):21-30. doi: 10.1016/j.biopsych.2016.07.004. Epub 2016 Jul 14.
5
The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.基因、压力和多巴胺在精神分裂症发病中的作用。
Biol Psychiatry. 2017 Jan 1;81(1):9-20. doi: 10.1016/j.biopsych.2016.07.014. Epub 2016 Aug 6.
6
Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study.精神分裂症患者前额叶皮质和纹状体以外区域多巴胺释放不足：一项正电子发射断层扫描功能磁共振成像研究。
JAMA Psychiatry. 2015 Apr;72(4):316-24. doi: 10.1001/jamapsychiatry.2014.2414.
7
Increased stress-induced dopamine release in psychosis.精神分裂症患者应激诱导的多巴胺释放增加。
Biol Psychiatry. 2012 Mar 15;71(6):561-7. doi: 10.1016/j.biopsych.2011.10.009. Epub 2011 Nov 30.
8
Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis.临床精神病高危人群中，额前叶异常激活与纹状体突触前多巴胺功能障碍直接相关。
Mol Psychiatry. 2011 Jan;16(1):67-75. doi: 10.1038/mp.2009.108. Epub 2009 Dec 1.
9
Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride.安非他明诱导的人类皮质多巴胺释放的正电子发射断层扫描成像：高亲和力多巴胺 D2/3 放射性示踪剂[11C]FLB 457 和[11C]法螺必利的比较评估
Synapse. 2009 Jun;63(6):447-61. doi: 10.1002/syn.20628.
10
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.前额叶活动减少预示着精神分裂症患者纹状体多巴胺能功能亢进。
Nat Neurosci. 2002 Mar;5(3):267-71. doi: 10.1038/nn804.

精神分裂症中的皮质多巴胺失调及其与应激的关系。

Cortical dopamine dysregulation in schizophrenia and its link to stress.

机构信息

Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, PA, USA.

出版信息

Brain. 2018 Jul 1;141(7):1897-1899. doi: 10.1093/brain/awy156.

DOI:10.1093/brain/awy156
PMID:30053178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6022591/
Abstract

This scientific commentary refers to ‘Cortical stress regulation is disrupted in schizophrenia but not in clinical high risk for psychosis’, by Schifani . (doi:10.1093/brain/awy133).

摘要

这篇科学评论提到了 Schifani 的研究“精神分裂症中皮质应激调节被破坏，但精神病临床高危人群中没有被破坏”。（doi:10.1093/brain/awy133）