IBIMA, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Málaga, 29071 Málaga, Spain.
IBIMA, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Málaga, 29071 Málaga, Spain.
Biochim Biophys Acta Rev Cancer. 2018 Dec;1870(2):158-164. doi: 10.1016/j.bbcan.2018.07.007. Epub 2018 Jul 24.
Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. The two types of glutaminase isoenzymes, GLS and GLS2, differ in their expression patterns and functional roles: GLS has oncogenic properties and GLS2 has been described as a tumour suppressor factor. Selective genomic and epigenomic intervention over glutaminase affects the metabolic reprogramming of cancer. This review highlights the molecular metabolic vulnerabilities in various types of cancer, to be used for biomarker development, drug design, and in personalized oncology.
细胞代谢改变是癌症的一个标志。癌细胞表达代谢酶的同工型，这些同工型可能成为治疗靶点。谷氨酰胺酶控制谷氨酰胺代谢，其表达与肿瘤的恶性程度相关。两种类型的谷氨酰胺酶同工酶，GLS 和 GLS2，在表达模式和功能作用上有所不同：GLS 具有致癌特性，而 GLS2 已被描述为肿瘤抑制因子。对谷氨酰胺酶的选择性基因组和表观遗传干预会影响癌症的代谢重编程。本综述强调了各种类型癌症中的分子代谢脆弱性，可用于生物标志物开发、药物设计和个性化肿瘤学。
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