给犬多次口服地西泮、奥沙西泮和苯巴比妥——行为效应及其与安替比林半衰期的相关性

Multiple oral doses of diazepam, oxazepam and phenobarbital to dogs--behavioural effects and correlation with antipyrine half-life.

作者信息

Albanus L, Jönsson M, Sparf B

出版信息

Acta Pharmacol Toxicol (Copenh). 1977 Jan;40 Suppl 1(1):63-9.

Abstract

The effects of prolonged treatment with phenobarbital, diazepam, and oxazepam on behaviour and on the plasma half-life of antipyrine have been studied in the dog. In this species the biotransformation of diazepam and oxazepam is known to be very similar to man. After equipotent doses of phenobarbital (25 mg/kg) and diazepam (35 mg/kg), antipyrine half-life was found to decrease 80 and 40%, respectively, while after treatment with oxazepam (150 mg/kg) there was an increase of 20%. The behavioural effects declined in the dogs during the course of treatment with diazepam but were rather constant during treatment with oxazepam.

摘要

已在犬中研究了苯巴比妥、地西泮和奥沙西泮长期治疗对行为及安替比林血浆半衰期的影响。已知在该物种中，地西泮和奥沙西泮的生物转化与人非常相似。给予等效剂量的苯巴比妥（25mg/kg）和地西泮（35mg/kg）后，发现安替比林半衰期分别缩短80%和40%，而给予奥沙西泮（150mg/kg）治疗后，半衰期增加20%。在用地西泮治疗过程中，犬的行为效应有所下降，但在用奥沙西泮治疗期间相当稳定。