Salzman C, Shader R I, Greenblatt D J, Harmatz J S
Arch Gen Psychiatry. 1983 Mar;40(3):293-7. doi: 10.1001/archpsyc.1983.01790030063008.
Oxazepam and diazepam were compared in healthy elderly volunteers. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more profound. Diazepam accumulation was extensive, washout was slow and active compounds were present two weeks after the last dose. Oxazepam accumulation was significantly less and elimination significantly faster than diazepam. There was no difference between oxazepam and diazepam in sedation or fatigue during the drug treatment, but sedative effects persisted for two weeks after diazepam therapy was discontinued. Sedation rapidly returned to baseline in the oxazepam group. Thus, the differing pharmacokinetic profiles of diazepam and oxazepam have clinical consequences during multiple dosage in the elderly.
在健康老年志愿者中对奥沙西泮和地西泮进行了比较。地西泮的吸收比奥沙西泮快，临床效果的起效更显著。地西泮的蓄积广泛，清除缓慢，在最后一剂后两周仍有活性化合物存在。奥沙西泮的蓄积明显少于地西泮，消除明显快于地西泮。在药物治疗期间，奥沙西泮和地西泮在镇静或疲劳方面没有差异，但地西泮治疗停止后，镇静作用持续了两周。奥沙西泮组的镇静作用迅速恢复到基线水平。因此，地西泮和奥沙西泮不同的药代动力学特征在老年人多次给药期间具有临床意义。
