Kellermann G H, Luyten-Kellermann M
Res Commun Chem Pathol Pharmacol. 1979 Feb;23(2):287-96.
The metabolism of antipyrine and oxazepam has been measured in twelve healthy subjects. Antipyrine, an analgesic and antipyretic drug, is extensively metabolized by oxidation at various sites and oxazepam, a benzodiazepine, is almost exclusively metabolized by conjugation with glucuronic acid. Comparing the plasma clearance rates and the plasma half lives of the two drugs, correlation coefficients of r = 0.766 (P less than 0.01) and r = 0.966 (P less than 0.01) have been obtained. The data suggests that in man the processes of oxidation and glucuronidation are linked by a common control which regulates the metabolic rates of the two reactions.
已对12名健康受试者的安替比林和奥沙西泮的代谢情况进行了测定。安替比林是一种止痛和解热药物，通过在不同位点的氧化作用被广泛代谢；奥沙西泮是一种苯二氮䓬类药物，几乎完全通过与葡萄糖醛酸结合进行代谢。比较这两种药物的血浆清除率和血浆半衰期，得到的相关系数分别为r = 0.766（P < 0.01）和r = 0.966（P < 0.01）。数据表明，在人体中，氧化和葡萄糖醛酸化过程由一个共同的调控机制相连，该机制调节这两种反应的代谢速率。
