关于人体中安替比林和奥沙西泮代谢的调节

On the regulation of antipyrine and oxazepam metabolism in man.

作者信息

Kellermann G H, Luyten-Kellermann M

出版信息

Res Commun Chem Pathol Pharmacol. 1979 Feb;23(2):287-96.

PMID:461954

Abstract

The metabolism of antipyrine and oxazepam has been measured in twelve healthy subjects. Antipyrine, an analgesic and antipyretic drug, is extensively metabolized by oxidation at various sites and oxazepam, a benzodiazepine, is almost exclusively metabolized by conjugation with glucuronic acid. Comparing the plasma clearance rates and the plasma half lives of the two drugs, correlation coefficients of r = 0.766 (P less than 0.01) and r = 0.966 (P less than 0.01) have been obtained. The data suggests that in man the processes of oxidation and glucuronidation are linked by a common control which regulates the metabolic rates of the two reactions.

摘要

已对12名健康受试者的安替比林和奥沙西泮的代谢情况进行了测定。安替比林是一种止痛和解热药物，通过在不同位点的氧化作用被广泛代谢；奥沙西泮是一种苯二氮䓬类药物，几乎完全通过与葡萄糖醛酸结合进行代谢。比较这两种药物的血浆清除率和血浆半衰期，得到的相关系数分别为r = 0.766（P < 0.01）和r = 0.966（P < 0.01）。数据表明，在人体中，氧化和葡萄糖醛酸化过程由一个共同的调控机制相连，该机制调节这两种反应的代谢速率。