Department of Medicine, Division of Gastroenterology and Hepatology, Endoscopy Unit, Alameda Health System-Highland Hospital Campus-Highland Care Pavilion 5th Floor, 1411 East 31st Street, Oakland, CA, 94602, USA.
Division of Gastroenterology and Hepatology, Stanford Health Care, Palo Alto, CA, USA.
Hepatol Int. 2018 Jul;12(4):315-329. doi: 10.1007/s12072-018-9884-8. Epub 2018 Jul 27.
Chronic hepatitis B virus infection (HBV) continues to pose a serious global health threat in many areas of the world, particularly in sub-Saharan Africa, the Western Pacific Region and areas of Eastern Europe. Endemicity is heterogeneous within and across regions owing to variable implementation of childhood and birth-dose vaccination programs, inconsistent screening of blood products, injection drug use, and poor education initiatives. This review aims to provide comprehensive up-to-date estimates of global seroprevalence of chronic HBV across six World Health Organization (WHO) regions, noting patterns of change over time and highlighting potential region-specific barriers to the diagnosis and elimination of HBV.
慢性乙型肝炎病毒感染（HBV）在世界许多地区，特别是撒哈拉以南非洲、西太平洋地区和东欧地区，仍然构成严重的全球健康威胁。由于儿童和出生时疫苗接种计划的实施情况不同、血液制品筛查情况不一致、注射吸毒以及教育举措不力，各区域内和区域之间的流行情况存在差异。本综述旨在提供全球六个世界卫生组织（世卫组织）区域慢性 HBV 血清流行率的最新综合估计数，同时注意随时间变化的模式，并突出乙型肝炎病毒诊断和消除方面可能存在的特定区域障碍。
