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利用机构利用数据和挽救生命工具(LiST)模拟大规模无线电宣传活动对儿童死亡率的影响:布基纳法索一项整群随机试验的结果

Modelling the effect of a mass radio campaign on child mortality using facility utilisation data and the Lives Saved Tool (LiST): findings from a cluster randomised trial in Burkina Faso.

作者信息

Murray Joanna, Head Roy, Sarrassat Sophie, Hollowell Jennifer, Remes Pieter, Lavoie Matthew, Borghi Josephine, Kasteng Frida, Meda Nicolas, Badolo Hermann, Ouedraogo Moctar, Bambara Robert, Cousens Simon

机构信息

Development Media International, London, UK.

Centre for Maternal Adolescent Reproductive and Child Health (MARCH), London School of Hygiene & Tropical Medicine, London, UK.

出版信息

BMJ Glob Health. 2018 Jul 16;3(4):e000808. doi: 10.1136/bmjgh-2018-000808. eCollection 2018.

Abstract

BACKGROUND

A cluster randomised trial (CRT) in Burkina Faso was the first to demonstrate that a radio campaign increased health-seeking behaviours, specifically antenatal care attendance, health facility deliveries and primary care consultations for children under 5 years.

METHODS

Under-five consultation data by diagnosis was obtained from primary health facilities in trial clusters, from January 2011 to December 2014. Interrupted time-series analyses were conducted to assess the intervention effect by time period on under-five consultations for separate diagnosis categories that were targeted by the media campaign. The Lives Saved Tool was used to estimate the number of under-five lives saved and the per cent reduction in child mortality that might have resulted from increased health service utilisation. Scenarios were generated to estimate the effect of the intervention in the CRT study areas, as well as a national scale-up in Burkina Faso and future scale-up scenarios for national media campaigns in five African countries from 2018 to 2020.

RESULTS

Consultations for malaria symptoms increased by 56% in the first year (95% CI 30% to 88%; p<0.001) of the campaign, 37% in the second year (95% CI 12% to 69%; p=0.003) and 35% in the third year (95% CI 9% to 67%; p=0.006) relative to the increase in the control arm. Consultations for lower respiratory infections increased by 39% in the first year of the campaign (95% CI 22% to 58%; p<0.001), 25% in the second (95% CI 5% to 49%; p=0.010) and 11% in the third year (95% CI -20% to 54%; p=0.525). Diarrhoea consultations increased by 73% in the first year (95% CI 42% to 110%; p<0.001), 60% in the second (95% CI 12% to 129%; p=0.010) and 107% in the third year (95% CI 43% to 200%; p<0.001). Consultations for other diagnoses that were not targeted by the radio campaign did not differ between intervention and control arms. The estimated reduction in under-five mortality attributable to the radio intervention was 9.7% in the first year (uncertainty range: 5.1%-15.1%), 5.7% in the second year and 5.5% in the third year. The estimated number of under-five lives saved in the intervention zones during the trial was 2967 (range: 1110-5741). If scaled up nationally, the estimated reduction in under-five mortality would have been similar (9.2% in year 1, 5.6% in year 2 and 5.5% in year 3), equating to 14 888 under-five lives saved (range: 4832-30 432). The estimated number of lives that could be saved by implementing national media campaigns in other low-income settings ranged from 7205 in Burundi to 21 443 in Mozambique.

CONCLUSION

Evidence from a CRT shows that a child health radio campaign increased under-five consultations at primary health centres for malaria, pneumonia and diarrhoea (the leading causes of postneonatal child mortality in Burkina Faso) and resulted in an estimated 7.1% average reduction in under-five mortality per year. These findings suggest important reductions in under-five mortality can be achieved by mass media alone, particularly when conducted at national scale.

摘要

背景

布基纳法索的一项整群随机试验(CRT)首次表明,无线电宣传活动增加了寻求医疗行为,特别是产前检查就诊率、医疗机构分娩率以及5岁以下儿童的初级保健咨询率。

方法

2011年1月至2014年12月期间,从试验群组的初级卫生设施获取了按诊断分类的5岁以下儿童咨询数据。进行了中断时间序列分析,以评估不同时间段内针对媒体宣传活动目标的不同诊断类别的5岁以下儿童咨询的干预效果。使用“挽救生命工具”来估计挽救的5岁以下儿童生命数量以及因增加卫生服务利用可能导致的儿童死亡率降低百分比。生成了各种情景,以估计CRT研究区域内干预措施的效果,以及布基纳法索全国范围的扩大规模情况,以及2018年至2020年五个非洲国家全国媒体宣传活动未来扩大规模的情景。

结果

与对照组的增加情况相比,在宣传活动的第一年,疟疾症状咨询增加了56%(95%置信区间30%至88%;p<0.001),第二年增加了37%(95%置信区间12%至69%;p=0.003),第三年增加了35%(95%置信区间9%至67%;p=0.006)。下呼吸道感染咨询在宣传活动的第一年增加了39%(95%置信区间22%至58%;p<0.001),第二年增加了25%(95%置信区间5%至49%;p=0.010),第三年增加了11%(95%置信区间 -20%至54%;p=0.525)。腹泻咨询在第一年增加了73%(95%置信区间42%至110%;p<0.001),第二年增加了60%(95%置信区间12%至129%;p=0.010),第三年增加了107%(95%置信区间43%至200%;p<0.001)。无线电宣传活动未针对的其他诊断的咨询在干预组和对照组之间没有差异。归因于无线电干预的5岁以下儿童死亡率估计在第一年降低了9.7%(不确定范围:5.1%-15.1%),第二年降低了5.7%,第三年降低了5.5%。试验期间干预区域挽救的5岁以下儿童生命估计数量为2967例(范围:1110 - 5741例)。如果在全国范围内扩大规模,估计5岁以下儿童死亡率的降低情况将相似(第一年9.2%,第二年5.6%,第三年5.5%),相当于挽救14888例5岁以下儿童生命(范围:4832 - 30432例)。在其他低收入环境中实施全国媒体宣传活动估计可挽救的生命数量范围从布隆迪的7205例到莫桑比克的21443例。

结论

一项整群随机试验的证据表明,一项儿童健康无线电宣传活动增加了初级卫生中心针对疟疾、肺炎和腹泻(布基纳法索新生儿期后儿童死亡的主要原因)的5岁以下儿童咨询,并导致估计每年5岁以下儿童死亡率平均降低7.1%。这些发现表明,仅通过大众媒体就可以大幅降低5岁以下儿童死亡率尤其在全国范围内开展时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d99b/6058176/4d7421d4210a/bmjgh-2018-000808f01.jpg

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