依他尼酸与链霉素的耳毒性相互作用。

Ototoxic interactions of ethacrynic acid and streptomycin.

作者信息

Mathog R H, Capps M J

出版信息

Ann Otol Rhinol Laryngol. 1977 Mar-Apr;86(2 pt. 1):158-63. doi: 10.1177/000348947708600204.

Abstract

Various aminoglycoside antibiotics and potent diuretics are known to depress cochlear and vestibular function. Several clinical and research studies suggest that the drugs administered together produce enhanced ototoxicity. The present series of experiments determines the depressive effects of ethacrynic acid and streptomycin, alone or in combination, upon the vestibular system of the cat. The changes in function, when quantified, indicate an addition, rather than a potentiation of toxicity, and suggest different sites of action.

摘要

已知多种氨基糖苷类抗生素和强效利尿剂会抑制耳蜗和前庭功能。多项临床和研究表明，同时使用这些药物会增强耳毒性。本系列实验确定了依他尼酸和链霉素单独或联合使用对猫前庭系统的抑制作用。功能变化经量化后表明，其毒性作用是相加而非增强，且提示作用部位不同。