Lee Jin Yong, Kang Sungchan, Bae Jung Min, Jo Seong Jin, Koh Seong-Joon, Park Hyun-Sun
Public Health Medical Service, SMG-SNU Boramae Medical Center, Seoul, Korea.
Institute of Health and Environment, Seoul National University, Seoul, Korea.
Indian J Dermatol Venereol Leprol. 2019 Mar-Apr;85(2):145-152. doi: 10.4103/ijdvl.IJDVL_875_17.
The epidemiology of the association between psoriasis and inflammatory bowel disease is poorly defined and remains controversial.
To evaluate the prevalence of inflammatory bowel disease in patients with psoriasis compared with the general population.
We searched the nationwide health claims database between 2011 and 2015 and evaluated the prevalence of inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Prevalence of inflammatory bowel disease, Crohn's disease and ulcerative colitis in patients with psoriasis vs the general population in 2011 were 0.16, 0.05 and 0.12% vs 0.08, 0.03 and 0.06%, respectively, which increased significantly with time between 2011 and 2015. Patients with psoriasis consistently revealed higher standardized prevalence (age and sex adjusted) of inflammatory bowel disease, Crohn's disease and ulcerative colitis compared with the general population. Subgroup analysis revealed the highest risk of prevalent inflammatory bowel disease in patients younger than 19 years (crude odds ratio 5.33, 95% confidence interval 3.74-7.59). Severe psoriasis demonstrated higher odds of inflammatory bowel disease (odds ratio 2.96, 95% confidence interval 2.54-3.45) than mild psoriasis (odds ratio 1.68, 95% confidence interval 1.51-1.88).
Limited data for doing adjustment and cross-sectional study design.
Psoriasis patients revealed higher risk of inflammatory bowel disease. In particular, young patients and those with severe psoriasis may require closer monitoring and comprehensive management.
银屑病与炎症性肠病之间关联的流行病学情况尚不明确，仍存在争议。
评估银屑病患者中炎症性肠病的患病率，并与普通人群进行比较。
我们检索了2011年至2015年的全国健康保险理赔数据库，评估了炎症性肠病（包括克罗恩病和溃疡性结肠炎）的患病率。
2011年银屑病患者中炎症性肠病、克罗恩病和溃疡性结肠炎的患病率分别为0.16%、0.05%和0.12%，而普通人群分别为0.08%、0.03%和0.06%，2011年至2015年期间患病率随时间显著增加。与普通人群相比，银屑病患者炎症性肠病、克罗恩病和溃疡性结肠炎的标准化患病率（年龄和性别校正后）始终较高。亚组分析显示，19岁以下患者患炎症性肠病的风险最高（粗比值比5.33，95%置信区间3.74 - 7.59）。重度银屑病患者患炎症性肠病的几率（比值比2.96，95%置信区间2.54 - 3.45）高于轻度银屑病患者（比值比1.68，95%置信区间1.51 - 1.88）。
用于调整的数据有限且为横断面研究设计。
银屑病患者患炎症性肠病的风险较高。特别是年轻患者和重度银屑病患者可能需要更密切的监测和综合管理。
