Hospital for Skin Disease (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Sino-French Hoffmann Institute, School of Basic Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Front Immunol. 2022 Jun 10;13:880201. doi: 10.3389/fimmu.2022.880201. eCollection 2022.
Psoriasis is a chronic autoimmune inflammatory disease that remains active for a long period, even for life in most patients. The impact of psoriasis on health is not only limited to the skin, but also influences multiple systems of the body, even mental health. With the increasing of literature on the association between psoriasis and extracutaneous systems, a better understanding of psoriasis as an autoimmune disease with systemic inflammation is created. Except for cardiometabolic diseases, gastrointestinal diseases, chronic kidney diseases, malignancy, and infections that have received much attention, the association between psoriasis and more systemic diseases, including the skin system, reproductive system, and oral and ocular systems has also been revealed, and mental health diseases draw more attention not just because of the negative mental and mood influence caused by skin lesions, but a common immune-inflammatory mechanism identified of the two systemic diseases. This review summarizes the epidemiological evidence supporting the association between psoriasis and important and/or newly reported systemic diseases in the past 5 years, and may help to comprehensively recognize the comorbidity burden related to psoriasis, further to improve the management of people with psoriasis.
银屑病是一种慢性自身免疫性炎症性疾病，在大多数患者中，该病会长期持续存在，甚至终生存在。银屑病对健康的影响不仅局限于皮肤，还会影响身体的多个系统，甚至心理健康。随着越来越多的文献报道银屑病与皮肤外系统之间的关联，人们对银屑病作为一种具有全身炎症的自身免疫性疾病有了更好的认识。除了已受到广泛关注的心脑血管代谢疾病、胃肠道疾病、慢性肾脏病、恶性肿瘤和感染外，银屑病与更多全身性疾病（包括皮肤系统、生殖系统和口腔和眼部系统）之间的关联也已被揭示，而心理健康疾病受到更多关注不仅是因为皮损引起的负面心理和情绪影响，还因为这两种全身性疾病存在共同的免疫炎症机制。本综述总结了过去 5 年中支持银屑病与重要和/或新报道的全身性疾病之间关联的流行病学证据，这可能有助于全面认识与银屑病相关的共病负担，从而进一步改善银屑病患者的管理。
