State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Chem Commun (Camb). 2018 Aug 14;54(66):9147-9150. doi: 10.1039/c8cc04428g.
The rhodium(iii)-catalyzed intramolecular annulation of alkyne-tethered 3-(indol-3-yl)-3-oxopropanenitriles for the synthesis of fused carbazole scaffolds via C-H activation has been developed. A series of six-, seven-, and eight-membered hydroazepino[3,2,1-jk]carbazoles were achieved. This reaction proceeded under mild reaction conditions and with a broad substrate scope. The reaction involved sequential cleavage of C(sp2)-H/C(sp3)-H bonds and annulation with the tethered alkyne.
铑(III)催化的炔烃键合的 3-(吲哚-3-基)-3-氧代丙腈的分子内环化反应，通过 C-H 活化合成稠合咔唑支架已经被开发出来。一系列六、七、八元的氢化氮杂环庚[3,2,1-jk]咔唑被合成出来。该反应在温和的反应条件下进行，具有广泛的底物范围。反应涉及到 C(sp2)-H/C(sp3)-H 键的顺序断裂和与键合的炔烃的环化。
