Department of Family Medicine, Yong-In Severance Hospital, Yonsei University College of Medicine.
Department of Medicine, Graduate School, Yonsei University.
J Glaucoma. 2018 Dec;27(12):1099-1104. doi: 10.1097/IJG.0000000000001036.
Elevated intraocular pressure (IOP) is an important modifiable risk factor predicting glaucoma progression. Recent studies have demonstrated that metabolic risk factors influence IOP. Nonalcoholic fatty liver (NAFLD) is an emerging chronic liver disease that is closely associated with metabolic syndrome, obesity, and type 2 diabetes. Therefore, we investigated the relationship between NAFLD and intraocular pressure in Korean adults.
This retrospective cross-sectional study analyzed a total of 7681 participants who visited a local health promotion center. NAFLD was defined via ultrasonography and patients were classified into 3 groups based on severity: normal, mild, and moderate to severe. We conducted multiple logistic regression analysis to examine the relationship between NAFLD and high IOP. We additionally performed multiple linear regression analysis to investigate the independent association between NAFLD and mean IOP.
Mean IOP levels significantly and linearly increased with increasing NAFLD grades. Compared with normal, the odds ratio and 95% confidence intervals for high IOP were 1.09 (0.96-1.24) for mild NAFLD and 1.28 (1.12-1.48) for moderate to severe NAFLD after adjusting for confounding factors. NAFLD severity was noticed as an independent factor associated with mean IOP levels using stepwise and enter methods for multiple linear regression analyses.
NAFLD severity was associated with high IOP (>15 mm Hg) in Korean adults in a dose-dependent manner.
眼内压（IOP）升高是预测青光眼进展的重要可调节危险因素。最近的研究表明，代谢危险因素会影响 IOP。非酒精性脂肪肝（NAFLD）是一种新兴的慢性肝脏疾病，与代谢综合征、肥胖和 2 型糖尿病密切相关。因此，我们调查了韩国成年人中 NAFLD 与眼内压之间的关系。
本回顾性横断面研究分析了共 7681 名前往当地健康促进中心就诊的参与者。通过超声检查定义 NAFLD，并根据严重程度将患者分为 3 组：正常、轻度和中重度。我们进行了多因素逻辑回归分析，以检查 NAFLD 与高 IOP 之间的关系。我们还进行了多元线性回归分析，以探讨 NAFLD 与平均 IOP 之间的独立关联。
平均 IOP 水平随着 NAFLD 严重程度的增加而显著呈线性升高。与正常相比，轻度 NAFLD 和中重度 NAFLD 发生高 IOP 的比值比及其 95%置信区间分别为 1.09（0.96-1.24）和 1.28（1.12-1.48），在调整混杂因素后。使用多元线性回归分析的逐步和进入方法，NAFLD 严重程度被认为是与平均 IOP 水平相关的独立因素。
NAFLD 严重程度与韩国成年人的高 IOP（>15mmHg）呈剂量依赖性相关。
