雌激素受体、孕激素受体及Akt在犬肛周腺肿瘤中的表达

Expression of Oestrogen Receptor, Progesterone Receptor and Akt in Canine Circumanal Gland Tumours.

作者信息

Kim S-H, Seung B-J, Cho S-H, Lim H-Y, Hwang J-H, Sur J-H

机构信息

Department of Veterinary Pathology, Small Animal Tumour Diagnostic Centre, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.

出版信息

J Comp Pathol. 2018 Jul;162:59-65. doi: 10.1016/j.jcpa.2018.06.006. Epub 2018 Jul 18.

DOI:10.1016/j.jcpa.2018.06.006

PMID:30060844

Abstract

We investigated the expression of oestrogen receptor alpha (OR-α), progesterone receptor (PR) and Akt in canine circumanal gland tumours. Immunohistochemistry was conducted on seven normal circumanal glands, 30 circumanal gland adenomas and 40 circumanal gland carcinomas. The expression of OR-α and PR was significantly lower in circumanal gland carcinomas than in circumanal gland adenomas. In contrast, the expression of Akt was markedly higher in circumanal gland carcinomas than in circumanal gland adenomas. These results indicate that the progression of canine circumanal gland tumours is influenced by changes in the expression levels of OR-α, PR and Akt. Identifying the molecular mechanisms of canine circumanal gland tumours requires further study.

摘要

我们研究了雌激素受体α（OR-α）、孕激素受体（PR）和Akt在犬肛周腺肿瘤中的表达情况。对7个正常肛周腺、30个肛周腺腺瘤和40个肛周腺癌进行了免疫组织化学检测。肛周腺癌中OR-α和PR的表达明显低于肛周腺腺瘤。相比之下，肛周腺癌中Akt的表达明显高于肛周腺腺瘤。这些结果表明，犬肛周腺肿瘤的进展受OR-α、PR和Akt表达水平变化的影响。确定犬肛周腺肿瘤的分子机制需要进一步研究。