Department of Pharmaceutical Microbiology at the Hans Knöll Institute, Friedrich-Schiller-University Jena, Winzerlaer Strasse 2, 07745 Jena, Germany.
Nat Prod Rep. 2019 Feb 20;36(2):307-325. doi: 10.1039/c8np00025e.
Covering: up to February 2018 In recent years, genome sequencing revealed the full biosynthetic potential of bacteria causing plant diseases. Bioinformatics and advanced analytical techniques paved the way to clarify the structures of long-sought natural products with a role in virulence. Furthermore, several compounds without disease-associated function were discovered. The exploration of these molecules disclosed persistence strategies of plant pathogenic bacteria outside their hosts and provided access to new bioactive compounds with therapeutic potential. In this review, we will summarize some of the striking findings in the field, paying particular attention to unique natural product pathways and their unprecedented biosynthetic features as well as the biological activities of the retrieved compounds.
截至 2018 年 2 月 近年来，基因组测序揭示了引起植物病害的细菌的全部生物合成潜力。生物信息学和先进的分析技术为阐明在致病作用中起关键作用的长期以来备受关注的天然产物的结构铺平了道路。此外，还发现了几种与疾病无关的化合物。这些分子的探索揭示了植物病原菌在宿主外的生存策略，并为具有治疗潜力的新型生物活性化合物提供了途径。在这篇综述中，我们将总结该领域的一些显著发现，特别关注独特的天然产物途径及其前所未有的生物合成特征以及所获得化合物的生物活性。
