INRA, Laboratoire des Interactions Plantes-Microorganismes, UMR441, F-31326 Castanet-Tolosan, France.
Annu Rev Phytopathol. 2012;50:67-89. doi: 10.1146/annurev-phyto-081211-173000. Epub 2012 May 1.
Ralstonia solanacearum is a major phytopathogen that attacks many crops and other plants over a broad geographical range. The extensive genetic diversity of strains responsible for the various bacterial wilt diseases has in recent years led to the concept of an R. solanacearum species complex. Genome sequencing of more than 10 strains representative of the main phylogenetic groups has broadened our knowledge of the evolution and speciation of this pathogen and led to the identification of novel virulence-associated functions. Comparative genomic analyses are now opening the way for refined functional studies. The many molecular determinants involved in pathogenicity and host-range specificity are described, and we also summarize current understanding of their roles in pathogenesis and how their expression is tightly controlled by an intricate virulence regulatory network.
青枯雷尔氏菌是一种主要的植物病原菌，可广泛攻击许多作物和其他植物。近年来，导致各种细菌性萎蔫病的菌株具有广泛的遗传多样性，这导致了青枯雷尔氏菌种复合体的概念。对代表主要系统发育群的 10 多个菌株进行基因组测序，拓宽了我们对该病原体进化和物种形成的认识，并确定了新的与毒力相关的功能。比较基因组分析现在为精细的功能研究开辟了道路。本文描述了参与致病性和宿主范围特异性的许多分子决定因素，并总结了目前对它们在发病机制中的作用的理解，以及它们的表达是如何通过一个复杂的毒力调控网络进行严格控制的。
