不同钠摄入水平大鼠给予钒酸盐后的血流动力学效应

Hemodynamic effects of vanadate administration in rats with different levels of sodium intake.

作者信息

Lopez-Novoa J M, Garrido M C

出版信息

Am J Med Sci. 1986 Mar;291(3):152-6. doi: 10.1097/00000441-198603000-00002.

DOI:10.1097/00000441-198603000-00002

Abstract

The acute hemodynamic effect of an intravenous (IV) bolus of vanadate (10 mumol/kg bwt) followed by an IV infusion at 0.5 mumol/kg min was studied in Wistar rats at three different levels of Na intake: low Na+ (0.5 mEq/24 h), normal Na+ (1.5 mEq/24 h), and high Na+ (15 mEq/24 h). Hemodynamic changes were measured using the radioactive microsphere method. Vanadate decreased cardiac output by 52.0 +/- 6.4% in low Na+ rats, by 41.2 +/- 3.3% in normal Na+, and by 29.2 +/- 3.1% in high Na+ group. Total peripheral resistances increased by 47.1 +/- 26% in high Na+ rats, by 80.1 +/- 6.6% in normal Na+, and by 96.3 +/- 4.5% in low Na+ group. Renal blood flow decreased by 70 +/- 4% in low Na+, 58 +/- 3% in normal Na+, and 39 +/- 3% in high Na+. Cerebral, testicular, and splanchnic blood flow showed smaller changes. These results demonstrate that intravenous vanadate induces marked hemodynamic changes that depend on Na+ intake being more striking when the intake of sodium is reduced.

摘要

在三种不同钠摄入量水平的Wistar大鼠中，研究了静脉推注钒酸盐（10 μmol/kg体重）后以0.5 μmol/kg·min的速度静脉输注钒酸盐的急性血流动力学效应：低钠（0.5 mEq/24 h）、正常钠（1.5 mEq/24 h）和高钠（15 mEq/24 h）。使用放射性微球法测量血流动力学变化。在低钠大鼠中，钒酸盐使心输出量降低了52.0±6.4%，在正常钠大鼠中降低了41.2±3.3%，在高钠组中降低了29.2±3.1%。总外周阻力在高钠大鼠中增加了47.1±26%，在正常钠大鼠中增加了80.1±6.6%，在低钠组中增加了96.3±4.5%。肾血流量在低钠时降低了70±4%，在正常钠时降低了58±3%，在高钠时降低了39±3%。脑、睾丸和内脏血流量变化较小。这些结果表明，静脉注射钒酸盐会引起明显的血流动力学变化，这种变化取决于钠的摄入量，当钠摄入量减少时更为显著。