Steffen R P, Pamnani M B, Clough D L, Huot S J, Muldoon S M, Haddy F J
Hypertension. 1981 May-Jun;3(3 Pt 2):I173-8. doi: 10.1161/01.hyp.3.3_pt_2.i173.
Vanadate, a potent naturally occurring Na+,K+-ATPase inhibitor thought to have a role in regulating Na+-K+ pump activity, was fed to uninephrectomized rats drinking tap water or a 1% solution of sodium chloride for as long as 56 weeks. Feeding was achieved by adding sodium orthovanadate to normal rat chow equivalent to 100 or 200 ppm vanadium by weight. In the rats drinking tap water, systolic pressure gradually increased over a period of several weeks and then was sustained in a dose-related manner for the duration of the treatment. The increased pressure was not associated with changes in water intake, urine output, or urinary sodium excretion but correlated positively with plasma vanadium levels ranging from 0.04 to 0.27 microgram/ml. Increased pressure was associated with increased heart-to-body-weight ratio but did not appear to occur in a small group of animals drinking the 1% solution of sodium chloride. These findings, considered in the light of others, indicate that vanadate deserves continued study in relation to hypertension.
钒酸盐是一种有效的天然存在的钠钾ATP酶抑制剂，被认为在调节钠钾泵活性方面发挥作用。将其喂给饮用自来水或1%氯化钠溶液的单侧肾切除大鼠，长达56周。通过向正常大鼠饲料中添加偏钒酸钠来实现喂食，添加量按重量计相当于100或200 ppm的钒。在饮用自来水的大鼠中，收缩压在几周内逐渐升高，然后在治疗期间以剂量相关的方式维持。血压升高与水摄入量、尿量或尿钠排泄的变化无关，但与血浆钒水平在0.04至0.27微克/毫升范围内呈正相关。血压升高与心脏与体重比增加有关，但在饮用1%氯化钠溶液的一小群动物中似乎未出现这种情况。结合其他研究结果来看，这些发现表明钒酸盐在高血压方面值得继续研究。
