Giuseppe Pistone, Nicola Pardo, Valentina Caputo, Elena Castelli, Salvatrice Curiale, Rosario Gurreri, Rita Bongiorno Maria
Section of Dermatology, Department of Biomedicine, Internal Medicine and Specialties (Di.Bi.MIS), University of Palermo, Palermo, Italy.
Ann Dermatol. 2018 Aug;30(4):462-464. doi: 10.5021/ad.2018.30.4.462. Epub 2018 Jun 27.
Hidradenitis suppurativa (HS) is a disorder of the apocrine gland causing a chronic, recurrent and painful inflammation. It is a disabilitating condition and, though many therapeutic options are available, the response is often ineffective in most cases and patients can present many recurrences with physical and psychological sequelae. Recent data had shown increased interleukin (IL)-17 serum levels in patients with HS. Psoriasis is a chronic immune-mediated inflammatory disorder and new evidences have shown the role of Th17 cells in its pathogenesis and the therapeutic efficacy of anti-IL-17 antibodies. We present a case of a patient suffering from psoriasis and HS successfully treated with anti-IL-17 antibodies for both conditions. This is the first case report of HS treated with secukinumab.
化脓性汗腺炎(HS)是一种顶泌汗腺疾病,可引发慢性、复发性且疼痛的炎症。它是一种致残性疾病,尽管有多种治疗选择,但在大多数情况下治疗效果往往不佳,患者可能会多次复发并伴有身体和心理后遗症。近期数据显示,HS患者血清白细胞介素(IL)-17水平升高。银屑病是一种慢性免疫介导的炎症性疾病,新证据表明Th17细胞在其发病机制中的作用以及抗IL-17抗体的治疗效果。我们报告一例同时患有银屑病和HS的患者,使用抗IL-17抗体成功治疗了这两种疾病。这是司库奇尤单抗治疗HS的首例病例报告。