Hacioglu Mayram, Birteksoz Tan Ayse Seher, Dosler Sibel, Inan Nese, Otuk Gulten
Department of Pharmaceutical Microbiology, Istanbul University, Istanbul, Turkey.
Department of Microbiology, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.
PeerJ. 2018 Jul 25;6:e5263. doi: 10.7717/peerj.5263. eCollection 2018.
may form biofilms, which are thought to underlie the most recalcitrant infections.
In this study, activities of antifungal agents alone and in combination with tigecycline against planktonic cells and mature and developing biofilms of isolates were evaluated.
Amphotericin B and echinocandins were found to be the most effective agents against mature biofilms, whereas the least effective agent was fluconazole. Furthermore, the most effective anti-fungal monotherapies against biofilm formation were amphotericin B and anidulafungin, and the least effective monotherapy was itraconazole. The combination of tigecycline and amphotericin B yielded synergistic effects, whereas combinations containing itraconazole yielded antagonist effects against planktonic cells. The combination of tigecycline and caspofungin exhibited maximum efficacy against mature biofilms, whereas combinations containing itraconazole exhibited minimal effects. Combinations of tigecycline with amphotericin B or anidulafungin were highly effective against biofilm formation.
In summary, tigecycline was highly active against particularly when combined with amphotericin B and echinocandins.
可能形成生物膜，而生物膜被认为是最难治疗的感染的基础。
在本研究中，评估了抗真菌药物单独使用以及与替加环素联合使用时对浮游细胞以及分离株的成熟和发育中的生物膜的活性。
发现两性霉素B和棘白菌素是对抗成熟生物膜最有效的药物，而最无效的药物是氟康唑。此外，对抗生物膜形成最有效的抗真菌单一疗法是两性霉素B和阿尼芬净，最无效的单一疗法是伊曲康唑。替加环素和两性霉素B的组合产生协同作用，而含有伊曲康唑的组合对浮游细胞产生拮抗作用。替加环素和卡泊芬净的组合对成熟生物膜表现出最大疗效，而含有伊曲康唑的组合表现出最小效果。替加环素与两性霉素B或阿尼芬净的组合对生物膜形成非常有效。
总之，替加环素对……具有高活性，特别是与两性霉素B和棘白菌素联合使用时。
