Masugi F, Ogihara T, Hasegawa T, Tomii A, Nagano M, Higashimori K, Kumahara K, Terano Y
Biochem Biophys Res Commun. 1986 Feb 26;135(1):41-5. doi: 10.1016/0006-291x(86)90939-3.
Circulating factor with ouabain-like immunoreactivity was studied in patients with primary aldosteronism. Anti-ouabain antibody was prepared from specific pathogen-free rabbits. In the plasma of patients with primary aldosteronism, the level of a factor with ouabain-like immunoreactivity was 2.59 +/- 1.39 pmol ouabain equivalent/ml plasma. This value was significantly (p less than 0.05) higher than that of age-matched normotensive subjects, 1.06 +/- 0.86 pmol ouabain equivalent/ml plasma. The plasma level of ouabain-like immunoreactivity correlated significantly (p less than 0.05) with blood pressure. These results indicate that the factor with ouabain-like immunoreactivity may play a pathophysiological role in the maintenance of the high blood pressure observed in patients with primary aldosteronism.
对原发性醛固酮增多症患者体内具有哇巴因样免疫反应性的循环因子进行了研究。从无特定病原体的兔子制备了抗哇巴因抗体。在原发性醛固酮增多症患者的血浆中，具有哇巴因样免疫反应性的因子水平为2.59±1.39 pmol哇巴因当量/毫升血浆。该值显著高于年龄匹配的血压正常受试者（p<0.05），后者为1.06±0.86 pmol哇巴因当量/毫升血浆。哇巴因样免疫反应性的血浆水平与血压显著相关（p<0.05）。这些结果表明，具有哇巴因样免疫反应性的因子可能在原发性醛固酮增多症患者高血压的维持中发挥病理生理作用。
