Masugi F, Ogihara T, Hasegawa T, Sakaguchi K, Kumahara Y
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
J Hum Hypertens. 1988 Jun;2(1):17-20.
Plasma ouabain-like immunoreactivity, which has been supposed to be associated with hypertension, was significantly higher in five patients with primary aldosteronism than in age-matched normotensive subjects. High plasma levels of ouabain-like immunoreactivity decreased to normal after removal of adenoma. Extracts of adenoma tissue did not contain any apparent ouabain-like immunoreactivity. Anti-ouabain antibody used in this study did not cross-react with aldosterone, cortisol, corticosterone, arachidonic acid or lysophosphatidylcholine. Hypertension, hypokalemia, a high plasma aldosterone level and low plasma renin activity were also normalized after surgery. These results indicate that hyperaldosteronism induces the high plasma level of ouabain-like immunoreactivity and this is associated in part with high blood pressure (BP) in primary aldosteronism.
血浆哇巴因样免疫反应性被认为与高血压有关，5例原发性醛固酮增多症患者的该指标显著高于年龄匹配的血压正常者。切除腺瘤后，高血浆水平的哇巴因样免疫反应性降至正常。腺瘤组织提取物未含有任何明显的哇巴因样免疫反应性。本研究中使用的抗哇巴因抗体与醛固酮、皮质醇、皮质酮、花生四烯酸或溶血磷脂酰胆碱无交叉反应。术后高血压、低钾血症、高血浆醛固酮水平和低血浆肾素活性也恢复正常。这些结果表明，醛固酮增多症诱导血浆中高哇巴因样免疫反应性水平，这在一定程度上与原发性醛固酮增多症中的高血压相关。
